Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

The EMBO Journal
Elena EnzoSirio Dupont

Abstract

Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic reprogramming is usually considered as a downstream consequence of tumor development and oncogene activation; growing evidence indicates, however, that metabolism on its turn can support oncogenic signaling to foster tumor malignancy. Here, we explored how glucose metabolism regulates gene transcription and found an unexpected link with YAP/TAZ, key transcription factors regulating organ growth, tumor cell proliferation and aggressiveness. When cells actively incorporate glucose and route it through glycolysis, YAP/TAZ are fully active; when glucose metabolism is blocked, or glycolysis is reduced, YAP/TAZ transcriptional activity is decreased. Accordingly, glycolysis is required to sustain YAP/TAZ pro-tumorigenic functions, and YAP/TAZ are required for the full deployment of glucose growth-promoting activity. Mechanistically we found that phosphofructokinase (PFK1), the enzyme regulating the first committed step of glycolysis, binds the YAP/TAZ transcriptional cofactors TEADs and promotes their functional and biochemical cooperation with YAP/TAZ. Strik...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E Bustamante, P L Pedersen
Jun 1, 1997·Genes & Development·J LukasJ Bartek
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jun 28, 2002·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Takashi TakahashiToyoaki Hida
Jun 12, 2003·Methods : a Companion to Methods in Enzymology·Jayanta DebnathJoan S Brugge
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder
Sep 23, 2003·Nature Cell Biology·Sophie PantalacciPierre Léopold
Feb 12, 2004·Cancer Research·Rodrigue RossignolRoderick A Capaldi
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Jan 19, 2007·The New England Journal of Medicine·Rui LiuMichael F Clarke
Mar 16, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa D MarroquinYvonne Will
Jun 10, 2008·Cancer Cell·Guido Kroemer, Jacques Pouyssegur
Jun 27, 2008·Genes & Development·Bin ZhaoKun-Liang Guan
Mar 28, 2009·The Journal of Biological Chemistry·Heng ZhangKun-Liang Guan
Apr 7, 2009·Cell·Maddalena AdornoStefano Piccolo
May 21, 2009·Experimental and Molecular Pathology·Abdullah YalcinJason Chesney
Oct 24, 2009·Nature Reviews. Cancer·Hui-Zi ChenGustavo Leone
Feb 4, 2010·Genes & Development·Ze LiYanhui Xu
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marco MazzoneJoan S Brugge
Mar 20, 2010·Nature Reviews. Cancer·Daniel A TennantEyal Gottlieb
Apr 7, 2010·Current Biology : CB·Nicola A GrzeschikHelena E Richardson
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Javier MenéndezGinés Morata
Oct 19, 2010·Developmental Cell·Duojia Pan

❮ Previous
Next ❯

Citations

Oct 27, 2015·Cellular and Molecular Life Sciences : CMLS·Zhaoyong Li, Huafeng Zhang
Jan 12, 2016·Trends in Cell Biology·Giulia SantinonSirio Dupont
Jan 5, 2016·Critical Reviews in Oncology/hematology·Marcello Maugeri-Saccà, Ruggero De Maria
May 6, 2015·Cell Cycle·Wenqi WangJunjie Chen
Jul 30, 2016·Oncoimmunology·Simonetta BuglioniMarcello Maugeri-Saccà
Sep 22, 2015·Frontiers in Oncology·Michael D DeelCorinne M Linardic
Aug 11, 2015·Nature Cell Biology·Francesca ZanconatoStefano Piccolo
Apr 22, 2016·Nucleic Acids Research·Alexey A SergushichevMaxim N Artyomov
Jun 15, 2016·Cancer Cell·Francesca ZanconatoStefano Piccolo
Jun 28, 2016·Trends in Biochemical Sciences·Aristeidis E BoukourisEvangelos D Michelakis
Jul 16, 2016·The International Journal of Biochemistry & Cell Biology·Fahim AhmadEllora Sen
Jul 15, 2016·Protein & Cell·Xin Zhou, Qun-Ying Lei
Jul 19, 2016·Nature Cell Biology·Andrew G CoxWolfram Goessling
Aug 23, 2016·The Journal of Clinical Investigation·Thomas BerteroStephen Y Chan
May 4, 2017·International Journal of Molecular Sciences·Maria FerraiuoloSabrina Strano
May 8, 2018·Cancers·Federica Lo SardoGiovanni Blandino
Dec 12, 2017·Frontiers in Physiology·Kevin I WattPaul Gregorevic
Oct 7, 2017·Cell Death and Differentiation·Noa FurthMoshe Oren
Apr 27, 2018·International Journal of Cancer. Journal International Du Cancer·Masahiro ShibataMohammad Obaidul Hoque
Sep 6, 2018·Annual Review of Genetics·Jyoti R Misra, Kenneth D Irvine
Jun 4, 2016·Molecular Medicine·Zhiqiang ZhaoLijun Di
Aug 26, 2018·EMBO Molecular Medicine·Alexander GreenhoughAnn C Williams
Oct 24, 2018·The EMBO Journal·Andrew G CoxWolfram Goessling
Jun 28, 2017·EMBO Reports·Magdalena PruszkoGiulia Fontemaggi
Feb 12, 2017·EMBO Reports·Emad Heidary ArashLiliana Attisano
Nov 2, 2019·Science Translational Medicine·Andrew J HaakDaniel J Tschumperlin
Dec 11, 2019·Journal of Clinical Medicine·Karla Santos-de-FrutosCorina Lorz
Feb 14, 2020·PloS One·Katarina ZmajkovicovaJohn Gatfield
Mar 13, 2020·The EMBO Journal·Pierre B CattenozAngela Giangrande
Dec 10, 2019·Journal of Cardiovascular Pharmacology·Toshihide Kashihara, Junichi Sadoshima
Dec 31, 2016·Oncotarget·June Sung BaeHo Lee
Apr 13, 2018·Cancers·Janine S A WarrenJohn M Lamar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.