Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction

BioMed Research International
Zhaoling ShiHeng Ma

Abstract

Cognitive dysfunction is an important complicated disease in obesity. Exercise ameliorates obesity and the related cognitive dysfunction. However, the underlying mechanism is still unclear. In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive dysfunction and the possible mechanism of SIRT3-MnSOD pathway. C57BL/6 wild-type (WT) mice and SIRT3 knockout (KO) mice were randomized into control (Con) or HFD group with or without AIT training for 6 weeks. The spatial learning and memory ability were impaired in HFD group compared to the control group. The levels of mitochondrial protein acetylation were increased in the hippocampus of HFD group. The acetylation level of antioxidative MnSOD was increased as well. As a result, the ROS and MDA levels were significantly increased, which leads to the neuron apoptosis in the hippocampus. SIRT3 deficiency further aggravated HFD-induced cognitive dysfunction and susceptibility to oxidative stress injury. However, AIT upregulated neuron SIRT3 expression and decreased the acetylation of MnSOD. The hippocampus neuron oxidative stress and apoptosis were both decreased compared to untrained HFD group, which finally improv...Continue Reading

References

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Citations

Sep 29, 2019·International Journal of Molecular Sciences·Francesca PacificiDavid Della-Morte
Jun 6, 2019·International Journal of Molecular Sciences·Katya Vargas-OrtizMaciste H Macías-Cervantes
Aug 28, 2019·Neurobiology of Disease·Joy Jones BuieCatrina Sims-Robinson
Jan 9, 2021·Frontiers in Neuroscience·Pavithra ChandramowlishwaranShanthi Srinivasan
Jun 10, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ricardo Augusto Leoni De SousaRicardo Cardoso Cassilhas

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Methods Mentioned

BETA
MDA
Assay
Coimmunoprecipitation
acetylation

Software Mentioned

Quantity One
GraphPad Prism
GraphPad
Pro Plus (
Leica DMLB )
Image
EthoVision

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis