Aerobic physical training increases contractile response and reduces cardiac fibrosis in rats subjected to early ovarian hormone deprivation

Journal of Applied Physiology
Ana Carolina S FelixHugo Celso Dutra de Souza

Abstract

We investigated the effects of early ovarian hormone deprivation on the heart and the role of physical training in this condition using different approaches: cardiac autonomic tone, contractility, morphology and function, and cardiac fibrosis. Female Wistar rats (n = 48) were assigned into two groups: ovariectomized (Ovx; 10-wk-old) and control rats (Sham; 10-wk-old). Each group was further divided into two subgroups, sedentary and trained (aerobic training by swimming for 10 wk). The sedentary groups showed similar cardiac autonomic tone values; however, only the Sham group had an increase in vagal participation for the determination of the basal heart rate after physical training. The contractile responses to cardiac β-agonists of the sedentary groups were similar, including an increased response to a β1-agonist (dobutamine) observed after physical training. The Ovx sedentary group presented changes in cardiac morphology, which resulted in decreases in the ejection fraction, fractional shortening, and cardiac index compared with the Sham sedentary group. Physical training did little to alter these findings. Moreover, histology analysis showed a significant increase in cardiac fibrosis in the sedentary Ovx group, which was not...Continue Reading

References

Nov 22, 1988·Neuroscience Letters·G PelletierM V Govindan
Mar 16, 1996·Lancet·Y T van der SchouwJ D Banga
Aug 15, 1996·The New England Journal of Medicine·F GrodsteinC H Hennekens
Feb 10, 1999·The American Journal of Physiology·T M Saleh, B J Connell
Oct 18, 2000·Brain Research Bulletin·J M KramerT G Waldrop
Dec 29, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·P QuK Hiwada
Oct 24, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C A GobattoE Kokubun
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Dec 13, 2002·Sports Medicine·James B CarterAndrew P Blaber
Feb 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Maria A CavasinXiao-Ping Yang
Mar 28, 2003·Brazilian Journal of Biology = Revista Brasleira De Biologia·F K MarcondesA P Tanno
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·André TchernofPierre Dupont
Jul 10, 2004·Exercise and Sport Sciences Reviews·Irving H ZuckerRainer U Pliquett
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Sophia N KalantaridouLampros K Michalis
Sep 28, 2004·Journal of Applied Physiology·Jack M GoodmanHoward J Green
Nov 27, 2004·Experimental Biology and Medicine·Paul S Cooke, Afia Naaz
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hong ZhengKaushik P Patel
Oct 4, 2005·Arquivos brasileiros de cardiologia·Nabil GhorayebGiuseppe S Dioguardi
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Claudia M M MarquesMarcia B Aguila
Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Femke AtsmaYvonne T van der Schouw
Aug 29, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gregory L BrowerJoseph S Janicki
Oct 31, 2006·Fertility and Sterility·Sophia N KalantaridouLawrence M Nelson
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keila T Higa-TaniguchiJavier E Stern
Apr 28, 2007·Cardiovascular Diabetology·Rogério WichiMaria Claudia Irigoyen
May 4, 2007·Menopause : the Journal of the North American Menopause Society·Rogerio A Lobo
May 29, 2007·Maturitas·Soung Hoon ChangSue Kyung Park
Sep 22, 2007·Current Opinion in Lipidology·Jean-François ArnalPierre Gourdy
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David S HydockReid Hayward
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Mehmet Akif DüzenliMehmet Tokac
Nov 4, 2008·Menopause : the Journal of the North American Menopause Society·Geisa C S V TeziniHugo C D Souza

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Citations

Nov 9, 2017·Archives of Physiology and Biochemistry·Faeze DaghighNaser Ahmadiasl
Jan 19, 2018·The Journal of Physiological Sciences : JPS·Fang-Hui LiTimon Cheng-Yi Liu
Feb 18, 2017·Oncotarget·Silvio A Oliveira-JuniorKatashi Okoshi
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Renáta SzabóAnikó Pósa
Sep 20, 2021·Experimental Gerontology·Sabrina Paula CostaAna Cristina Rodrigues Lacerda

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