Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women.

European Journal of Applied Physiology
Suzanne Broadbent, G C Gass

Abstract

The purpose of the present study was to determine whether 12 months of moderate intensity cycling would increase the expression of IL-2 (CD25+) receptors in T helper (CD4+) lymphocytes in men and women aged 65-75 years. Fourteen men and 10 women completed 52 weeks of moderate intensity cycling (60% VO2peak). Subjects trained (TR) three times per week for 45 min per session. Eight age-matched untrained (UT) male and eight UT female subjects acted as controls. Resting blood samples were taken from TR and UT subjects every 4 weeks. Leukocyte concentration was measured using a full blood count. PHA-stimulated CD4+ lymphocytes were analysed for changes in the expression of CD25+, by flow cytometry. Training significantly increased VO2peak (l min(-1), ml kg(-1) min(-1)) in male (+14.3, +16%) and female (+16.7, +27.8%) groups. The TR male group showed a significantly lower percentage of CD4+CD25+ than the male UT in January but the TR male percentage was significantly higher than the UT male group during February, March, April, May, June, September B and December. The female TR group showed a significantly higher percentage CD4+CD25+ than the female UT only during July. There were also significant sequential monthly changes in the per...Continue Reading

References

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Citations

Oct 3, 2012·Advances in Hematology·Alexander J AmbinderChristopher R Flowers
Apr 27, 2016·Medicine and Science in Sports and Exercise·Suzanne Broadbent, Rosanne Coutts

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