Aerodynamic characteristics of nebulized terbutaline sulphate using the Andersen Cascade Impactor compared to the Next Generation Impactor

Pharmaceutical Development and Technology
Mohamed E Abdelrahim

Abstract

Characterization of the aerosol emitted from nebulizers is determined using the Next Generation Impactor (NGI). The Andersen Cascade Impactor (ACI) was previously used but the limitation of high flow rate used decreased its uses. We have investigated the use of ACI with different operational conditions compared to the NGI methodology. NGI was operated at a flow rate of 15 L min⁻¹ after cooling at 5°C for 90 min. ACI was operated using flow rates 15 and 28.3 L min⁻¹ at room (ROOM) temperature and after cooling at 5 °C for 60 min (COLD). ACI was also operated using a flow rate 15 L min⁻¹ through the nebulizer T-piece with a flow rate 28.3 L min⁻¹ through ACI (15 Mix) using the mixing valve at ROOM and COLD. Two nebulizer systems, the Sidestream (SIDE) and the Aeroneb Pro (AERO) were used to nebulize terbutaline sulphate respiratory solution. Overall there was a highly significant difference (P < 0.001) between different ACI operating conditions for FPF and MMAD of both nebulizer systems. The ACI at higher flow rate increased the evaporation effect whilst cooling minimized evaporation of both nebulizer systems. Hence cooling and using slow flow rate minimizes evaporation effects with ACI. The ACI 15COLD results were similar to tha...Continue Reading

References

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Apr 28, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Mohamed E Abdelrahim, Henry Chrystyn

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Citations

May 1, 1966·American Industrial Hygiene Association Journal·R A Gussman, D Gordon
May 2, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hui Xin OngPaul M Young
Aug 6, 2016·Pharmaceutical Development and Technology·Muhammad H E ElHansyMohamed E A Abdelrahim
Jul 18, 2018·Journal of Oleo Science·Noor Hafizah ArbainMohd Basyaruddin Abdul Rahman
May 20, 2016·International Journal of High Risk Behaviors & Addiction·Mojtaba SalmabadiShadi Zolfaghari
Mar 16, 2018·Drug Delivery and Translational Research·Noor Hafizah ArbainMohd Basyaruddin Abdul Rahman
Dec 6, 2020·International Journal of Clinical Practice·Basma M E MohamedRaghda R S Hussein
Dec 7, 2020·International Journal of Clinical Practice·Yasmin M MadneyMohamed E A Abdelrahim
Jun 13, 2021·International Journal of Clinical Practice·Mona A AbdelrahmanHaitham Saeed

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