Aeromonas salmonicida resistance to complement-mediated killing.

Infection and Immunity
S MerinoJ M Tomás

Abstract

The resistance of Aeromonas salmonicida to complement-mediated killing was investigated by using different strains and their isogenic mutants that had been previously characterized for their surface components. We found that the classical complement pathway is involved in serum killing of susceptible A. salmonicida strains, while the alternative complement pathway seems not to be involved. All of the A. salmonicida strains are able to activate complement, but the smooth strains (with or without the A-layer) are resistant to complement-mediated killing. The reasons for this resistance are that C3b may be bound far from the cell membrane and that it is rapidly degraded; therefore, the lytic final complex C5b-9 (membrane attack complex) is not formed. Isogenic rough mutants are serum sensitive because they bind more C3b than the smooth strains, and if C3b is not completely degraded, then the lytic complex (C5b-9) is formed.

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Citations

Jan 1, 2012·ISRN Microbiology·J M Tomás
Apr 16, 2002·Molecular Microbiology·Tâm MignotAgnès Fouet
Jan 20, 2009·Journal of Bacteriology·Natalia JimenezJuan M Tomás
Dec 5, 2003·Journal of Fish Diseases·A NematollahiF Haesebrouck
Mar 2, 1999·Applied and Environmental Microbiology·C AmaroE Alcaide
May 1, 1997·Microbial Pathogenesis·S MerinoF Congregado

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