PMID: 7547353Jan 1, 1995Paper

Aerosol administration of antibiotics

Pediatric Pulmonology. Supplement
A L Smith, B Ramsey

Abstract

Antibiotics can be aerosolized to the lower respiratory tract of patients with pulmonary infections. With attention to stability of the antibiotic, its ability to be aerosolized, and particle size of the aerosol, rational design of an antibiotic aerosol treatment regimen is possible. The choice of nebulizer for aerosol antibiotic administration depends not only on drug stability under the nebulization conditions, but practical considerations such as ease of use in the home and expense. In general, a greater volume of respirable aerosol is generated by an ultrasonic device in comparison to the jet nebulizers. Of the factors affecting antibiotic delivery to the lower respiratory tract, the patients and their disease are the most important. This patient effect is not directly amenable to medical intervention, but can be controlled through measurement of antibiotic concentrations in respiratory secretions, seeking a target estimated from the best available in vitro data.

References

Sep 4, 1975·The New England Journal of Medicine·T W FeeleyD S Feingold
Nov 20, 1975·The New England Journal of Medicine·S A Berger, M Barza
Jan 1, 1989·Pediatric Pulmonology·G SteinkampH von der Hardt
Jan 1, 1974·Scandinavian Journal of Infectious Diseases·G E HoffJ Paulsen
Jun 17, 1993·The New England Journal of Medicine·B W RamseyM A McBurnie

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Citations

Jun 27, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Kenneth Manby PedersenHenning Gjelstrup Kristensen
Mar 17, 2004·Current Opinion in Infectious Diseases·Michael E Klepser
Sep 24, 1999·Chest·P W Campbell, L Saiman
Feb 21, 1998·The Journal of Pediatrics·M RosenfeldB Ramsey
Dec 22, 1999·Therapeutic Drug Monitoring·P P Le BrunH G Heijerman
Jul 1, 1996·The Annals of Pharmacotherapy·C TosoP G Noone

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