PMID: 9449495Feb 4, 1998Paper

Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma. The American Academy of Allergy, Asthma and Immunology Beclomethasone Dipropionate-Theophylline Study Group

The Journal of Allergy and Clinical Immunology
C E ReedD G Tinkelman

Abstract

Inhaled corticosteroids and oral theophylline are effective treatments for moderate asthma. We sought to compare the benefits and adverse reactions of theophylline and aerosol beclomethasone spray. A multicenter, double-blind, double-placebo, randomized, controlled trial of 1-year duration was performed. Seven hundred forty-seven patients with asthma received either beclomethasone dipropionate aerosol spray (84 microg four times per day) or sustained-release theophylline twice per day in doses adjusted for optimum control of the disease. The main outcome measures were daily diary of symptoms and peak flow rates (recorded on a mark-sense computer-readable form); supplemental bronchodilator use; doctor's office or hospital visits and absence from work or school; spirometry; methacholine testing; adverse experiences; and cortisol blood measurements. Both treatment strategies reduced symptoms promptly and achieved low absenteeism from work or school and low rates of emergency treatment for asthma. Both maintained nearly normal pulmonary function. Beclomethasone was statistically significantly more effective in reducing symptoms, supplemental bronchodilator and systemic glucocorticoid doses, bronchial hyperresponsiveness, and eosino...Continue Reading

References

Apr 1, 1986·The Journal of Allergy and Clinical Immunology·C E Reed
Nov 1, 1987·The American Review of Respiratory Disease·A S Buist
Nov 1, 1987·The American Review of Respiratory Disease·J I DutoitA J Woolcock
Feb 1, 1980·The Journal of Allergy and Clinical Immunology·J H ToogoodL Chuang
Jul 1, 1995·The European Respiratory Journal·C SchudtA Hatzelmann
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·J KidneyP J Barnes
Mar 1, 1993·The American Review of Respiratory Disease·A J WardJ F Costello
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·A K KamadaR F Lemanske
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·A B Kay
Aug 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S P GalantD J Kellerman
Jan 1, 1960·Journal of Clinical Pathology·M S DUNNILL

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Citations

Mar 11, 2005·The Journal of Pediatrics·Benjamin D Gold
Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J S Seggev
Aug 6, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Laura J PeekCory Berkland
May 17, 2000·Current Opinion in Pulmonary Medicine·J C KipsR A Pauwels
Jan 15, 1999·BMJ : British Medical Journal·N Roche
Mar 8, 2003·American Journal of Respiratory and Critical Care Medicine·Peter J Barnes
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro ItoPeter J Barnes
May 8, 2015·Lung India : Official Organ of Indian Chest Society·Ritesh AgarwalSubhash Varma
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Mitchell P DombrowskiUNKNOWN National Heart, Lung, and Blood Institute
May 23, 2014·The American Journal of Medicine·Michael E Wechsler
Nov 2, 2013·Clinical Reviews in Allergy & Immunology·T E AlbertsonS Louie
Nov 30, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Sohei MakinoUNKNOWN Asthma Prevention and Management Guidelines Committee
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·David B Allen
Aug 1, 2007·Expert Review of Respiratory Medicine·David B Allen
Nov 25, 1998·Pediatric Annals·M J Welch
Dec 8, 2004·Clinical Pediatrics·Nemr S Eid, UNKNOWN National Asthma Education and Prevention Program
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R LouisM Radermecker
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C J ReynoldsD Proud
Jan 27, 2006·The Cochrane Database of Systematic Reviews·P SeddonT J Lasserson
Nov 6, 2009·Journal of Microencapsulation·Arash Momeni, Mohammad H Mohammadi
Apr 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Servet OzkirazBerkan Gurakan
Mar 19, 2021·Allergy, Asthma & Immunology Research·Mai IshiiTakeshi Kaneko
May 23, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Harold S Nelson

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