Aerosol delivery during mechanical ventilation to the rat

Experimental Lung Research
Christian HofstetterB Zwissler

Abstract

The authors have adjusted a jet nebulizer to a mechanical ventilator (Servo Ventilator, Siemens) to deliver an aerosol to rats. They aimed to clarify whether a modified jet nebulizer generating particles with a mass median aerodynamic diameter of 2 microm would be effective and safe in intubated ventilated rats. Fluorescent microspheres (diameter: 1.0 microm) were aerosolized to verify qualitatively and quantitatively intrapulmonary deposition. Particle deposition fraction was 3.8% (1.3%) of the delivered dose (median [interquartile range]). There was no evidence for any adverse event as assessed from heart rate, mean arterial pressure, PaO2 and PaCO2 before, during, and after nebulization. No pulmonary tissue trauma was detected histologically.

References

Aug 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·Y L Lai, J Hildebrandt
May 1, 1992·Journal of Pharmacological and Toxicological Methods·D RaeburnM E Villamil
Feb 1, 1990·The American Review of Respiratory Disease·H D FullerM T Newhouse
Feb 1, 1985·Critical Care Medicine·N R MacIntyreR E Coleman
Aug 1, 1971·Diabetes·F W WigleyR H Waldman
Jul 1, 1969·Journal of Applied Physiology·F Palecek
Dec 1, 1993·Microscopy Research and Technique·K E PinkertonB K Tarkington
May 1, 1993·Journal of Applied Physiology·R W GlennyM Brinkley
Jun 1, 1996·British Journal of Pharmacology·C FornhemK Alving
Oct 1, 1995·Journal of Pharmaceutical Sciences·A Y IpR W Niven
Mar 1, 1997·Journal of Applied Physiology·H T RobertsonD Covert
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R Dhand, M J Tobin
Jan 1, 1996·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·M R SheldonW D Thompson
Jan 15, 1998·Critical Care Medicine·L B PalmerA Cuccia
Jan 27, 1998·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M Osier, G Oberdörster
Dec 4, 1994·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M DahlbäckB Jonson
Jul 20, 1999·Journal of Applied Physiology·W G KreylingA Ziesenis
Jan 5, 2000·Life Sciences·F SquadritoA P Caputi
Feb 5, 2000·Computer Methods and Programs in Biomedicine·E TheinK Messmer
Feb 28, 2002·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·G KemmingB Zwissler
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis

❮ Previous
Next ❯

Citations

May 14, 2010·American Journal of Respiratory Cell and Molecular Biology·Sandra HoeglHeiko Muhl
Oct 11, 2005·Critical Care Medicine·Christian HofstetterBernhard Zwissler
Nov 14, 2008·Respiratory Medicine·Sandra HoeglChristian Hofstetter
May 7, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ronan J MacLoughlinTimothy O'Brien
Apr 16, 2009·Intensive Care Medicine·Patrick ScheiermannChristian Hofstetter
May 16, 2009·European Journal of Anaesthesiology·Michael FlondorChristian Hofstetter
Feb 13, 2021·Frontiers in Pharmacology·Chunjue YuanYunbao Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.