Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice

Molecular Cancer Therapeutics
Hua JinChong Su Cho

Abstract

The low efficiency of conventional therapies in achieving long-term survival of patients with lung cancer calls for development of novel treatment options. Although several genes have been investigated for their antitumor activities through gene delivery, problems surrounding the methods used, such as efficiency, specificity, and toxicity, hinder application of such therapies in clinical settings. Aerosol gene delivery as nonviral and noninvasive method for gene therapy may provide an alternative for a safer and more effective treatment for lung cancer. In this study, imidazole ring-containing urocanic acid-modified chitosan (UAC) designed in previous study was used as a gene carrier. The efficiency of UAC carrier in lungs was confirmed, and the potential effects of the programmed cell death protein 4 (PDCD4) tumor suppressor gene on three major pathways (apoptosis, cell cycle, and angiogenesis) were evaluated. Aerosol containing UAC/PDCD4 complexes was delivered into K-ras null lung cancer model mice through the nose-only inhalation system developed by our group. Delivered UAC/PDCD4 complex facilitated apoptosis, inhibited pathways important for cell proliferation, and efficiently suppressed pathways important for tumor angiog...Continue Reading

References

Aug 11, 1995·The Journal of Biological Chemistry·J ZabnerM J Welsh
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·N S PellegataE J Stanbridge
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·K Y LeeS Y Jeong
Aug 28, 1998·Science·D R Green, J C Reed
Feb 25, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G CoxK J O'Byrne
Feb 13, 2001·Cardiovascular Research·M J PostM Simons
Feb 22, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H Q MaoK W Leong
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cheol-Hee AhnSung Wan Kim
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jun WangKam W Leong
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mini Thomas, Alexander M Klibanov
Dec 4, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tae Hee KimChong Su Cho
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alan B SandlerRoy S Herbst
Aug 20, 2004·American Journal of Physiology. Cell Physiology·R GökeB Lankat-Buttgereit
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mi Ran ParkChong Su Cho
Jun 21, 2005·Journal of Cellular Physiology·Mario CaputiAntonio Giordano

❮ Previous
Next ❯

Citations

Jan 8, 2010·International Journal of Nanomedicine·Heidi M MansourXiao Wu
Oct 31, 2012·International Journal of Molecular Sciences·Paul ZarogouldisKonstantinos Zarogoulidis
Sep 6, 2012·Therapeutic Delivery·Paul ZarogoulidisKonstantinos Zarogoulidis
Jan 29, 2013·Biomedical Microdevices·Jonghyun OhAli Khademhosseini
Nov 26, 2014·Expert Opinion on Drug Delivery·Seong-Ho HongMyung-Haing Cho
Mar 6, 2008·Expert Opinion on Drug Delivery·Yuanyuan XieTimothy S Wiedmann
Dec 3, 2011·Biochemical and Biophysical Research Communications·Nicolas FischerJörg Ellinger
Dec 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaojun ChenXiaohua Gong
Dec 9, 2016·Human Gene Therapy·Dolan SondhiRonald G Crystal
Sep 23, 2014·Biochimica Et Biophysica Acta·Jennifer Chu, Jerry Pelletier
Oct 13, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ali DabbaghNoorsaadah Abdul Rahman
Jan 9, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiaoyan WangXiaoyan Wang
May 29, 2018·Biology of the Cell·Qing Wang, Hsin-Sheng Yang
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Soon-Kyung HwangMyung-Haing Cho
Sep 17, 2008·Journal of Cellular and Molecular Medicine·Fei GaoLining Zhang
Jun 6, 2009·Cancer Science·Zeng-Tao WeiLi-Ning Zhang
May 19, 2011·Macromolecular Rapid Communications·In-Kyu ParkChong-Su Cho
Nov 24, 2011·Macromolecular Bioscience·Felipe A Oyarzun-AmpueroDolores Torres
Aug 10, 2013·Journal of Biomedical Materials Research. Part a·You-Kyoung KimHu-Lin Jiang
Apr 10, 2009·Biology of the Cell·Brigitte Lankat-Buttgereit, Rüdiger Göke
Sep 1, 2009·Cancer Informatics·Xiaosheng Wang, Osamu Gotoh
Feb 26, 2008·Cancer Research·Tobias SchmidNancy H Colburn
May 7, 2021·Journal of Immunotoxicology·Leonor de BragancaJeremy P Derrick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis