PMID: 8586115Oct 1, 1995Paper

Aerosol derived airway morphometry in healthy subjects

The European Respiratory Journal
P BrandJ Heyder

Abstract

Monodisperse aerosol particles can be used to non-invasively probe intrapulmonary airspace dimensions. In this study, the aerosol-derived airway morphometry technique was used to study airspace dimensions in 79 healthy subjects, in order to assess reference data for the future clinical application of aerosol-derived airway morphometry, and to investigate the effect of lung inflation, anthropometric, and lung function parameters on aerosol-derived airway morphometry. Intrapulmonary airspace dimensions were assessed by measuring the deposition of monodisperse, hydrophobic submicron aerosol particles during breathholding. Additionally, measurements of spirometric and body plethysmographic lung function were performed. Airspace dimensions were in good agreement with morphometric lung data. Airspace dimensions increased with increasing lung inflation. Interindividual variation of airspace dimensions was lowest in the lung periphery, at high levels of lung inflation, and when the volumetric lung depth was normalized to the end-inspiratory lung volume. Analysis of variance showed an increase of airspace dimensions with age. The results of this study indicate that aerosol-derived airway morphometry is dependent on the level of lung inf...Continue Reading

Citations

Sep 30, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M KohlhäuflJ Heyder
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P BrandT Kraus
Oct 11, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Winfried MöllerWolfgang G Kreyling
Jul 8, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Winfried MöllerWilliam D Bennett
May 27, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Andreas HenningClaus-Michael Lehr
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·M KohlhäuflJ Heyder
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Barnaby WatersMike Silverman
Oct 13, 2007·American Journal of Respiratory and Critical Care Medicine·Winfried MöllerWolfgang G Kreyling
Jan 21, 2006·Respiratory Research·Winfried MöllerJoachim Heyder
Nov 8, 2016·Scientific Reports·Jonas K F JakobssonJakob Löndahl
Sep 7, 2004·Journal of Applied Physiology·Winfried MöllerJoachim Heyder
Sep 14, 1999·Journal of Applied Physiology·K L ZemanW D Bennett
Oct 7, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Sabine HäussermannGerhard Scheuch

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