Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis

The European Respiratory Journal
M E WylamP M Anderson

Abstract

Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) auto-antibodies have been found in many patients with pulmonary alveolar proteinosis (PAP). The present study reports a retrospective case series of patients who used aerosolised GM-CSF in the treatment of idiopathic PAP. Between 1999 and 2003, 12 patients elected to receive aerosolised GM-CSF (250 microg b.i.d. every other week) in lieu of whole-lung lavage or observation. Patient characteristics, pulmonary function tests, arterial blood gas analysis, laboratory values and chest radiographs were extracted from the patient's medical records. Of the six patients tested, all had GM-CSF neutralising antibodies. Additionally, abnormalities in GM-CSF gene expression (one patient), receptor expression (two patients) and ability to upregulate adhesion molecules (one patient) were found. All patients except one had a positive response (mean improvements in arterial oxygen tension, alveolar-arterial oxygen gradient, carbon monoxide diffusing capacity of the lung and forced vital capacity were 17.1 mmHg, 18.4 mmHg, 16.6% pred and 13.5% pred, respectively). Two patients made a complete recovery and were disease free 1 and 2 yrs after discontinuing treatment. Four patients...Continue Reading

Citations

Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Frederic GagnadouxEtienne Lemarie
May 30, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Zhihao XuJiaoli Wang
Oct 6, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Steffen LethOle Hilberg
Feb 20, 2010·American Journal of Respiratory and Critical Care Medicine·Ryushi TazawaKoh Nakata
Sep 11, 2012·Multidisciplinary Respiratory Medicine·Ilaria CampoMaurizio Luisetti
Aug 11, 2011·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Ryushi Tazawa, Koh Nakata
Dec 25, 2013·The Journal of Infectious Diseases·Renuka SubramaniamHomayoun Shams
Apr 24, 2014·The Journal of Infectious Diseases·Renuka Subramaniam, Homayoun Shams
Apr 14, 2015·Expert Review of Respiratory Medicine·Spyros A PapirisEffrosyni D Manali
Aug 11, 2010·Expert Opinion on Biological Therapy·Sabina A Antoniu
Mar 17, 2009·Archivos de bronconeumología·José Antonio Rodríguez PortalAntonio Sánchez Garrido
Oct 15, 2014·Advanced Drug Delivery Reviews·Sebastian P HertelWolfgang Friess
Dec 17, 2014·Revue des maladies respiratoires·S JouneauP Delaval
Oct 11, 2014·Hematology/oncology and Stem Cell Therapy·Chakra P ChaulagainJohn K Erban
Nov 25, 2011·Respiratory Medicine·Kazumasa OhashiRyushi Tazawa
Jul 22, 2010·Therapeutic Advances in Respiratory Disease·Maurizio LuisettiBruce C Trapnell
Jul 25, 2019·Pharmaceutics·Brandon Banaschewski, Thomas Hofmann
Jan 31, 2014·The Journal of the Association of Physicians of India·Ruchira P ShendeSatish Kulkarni
Sep 5, 2019·The New England Journal of Medicine·Ryushi TazawaKoh Nakata
Jun 9, 2020·Expert Opinion on Pharmacotherapy·Sabina Antonela AntoniuIleana Antohe
Jun 23, 2020·Journal of Bronchology & Interventional Pulmonology·Daniel C VisPaul R MacEachern
Mar 14, 2019·Current Opinion in Pulmonary Medicine·Ilaria Campo
Mar 9, 2019·Nature Reviews. Disease Primers·Bruce C TrapnellCormac McCarthy
Sep 9, 2020·The New England Journal of Medicine·Bruce C TrapnellUNKNOWN IMPALA Trial Investigators
Dec 30, 2016·Respirology Case Reports·Armando J Huaringa, Wassem H Francis
Aug 2, 2017·Annals of the American Thoracic Society·Cliff Morgan
Mar 4, 2021·Orphanet Journal of Rare Diseases·Masaki HiroseYoshikazu Inoue

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