PMID: 6401778Feb 1, 1983Paper

Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection

The Journal of Hygiene
R B FitzgeorgeP J Dennis

Abstract

Infection of guinea-pigs by intranasal (i.n.) instillation of 10(9) viable organisms of two newly isolated strains of Legionella pneumophila (74/81, serogroup 1; 166/81, serogroup 3) did not induce disease, but 10(4) organisms administered as a small particle aerosol (less than 5 microns diameter) produced a fatal widespread broncho-pneumonia within 3 days. Milder illness and less extensive bronchopneumonia were also produced in rhesus monkeys and marmosets by one of these two strains (74/81). Mice were resistant to induction of disease by aerosols of both these two strains, though organisms did persist in the lungs for at least 4 days. Both of these L. pneumophila strains were pathogenic for guinea-pigs by aerosol infection over a wide range of doses but the serogroup 1 type strain (NCTC 11192) was not. There was no mortality after infection of guinea-pigs by intranasal instillation of any of these strains but all proved to be fatal after intraperitoneal (i.p.) injection of large doses. Guinea-pigs, rhesus monkeys and marmosets exposed to aerosol infection with L. pneumophila provide relevant models for studying the pathogenesis of Legionnaires' disease.

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Citations

Apr 9, 2010·Clinical Microbiology Reviews·Hayley J NewtonElizabeth L Hartland
Mar 26, 2014·Current Microbiology·Sham LalSt John Crean
Sep 26, 2013·The Journal of Hospital Infection·P CassierS Jarraud
Apr 1, 1987·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·M NowickiJ Fleurette
Aug 22, 2015·International Journal of Medical Microbiology : IJMM·Christian LückKlaus Heuner
Dec 21, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·T W Armstrong, C N Haas
May 1, 1985·The Journal of Infection·R B FitzgeorgeA Baskerville
Nov 1, 1983·The Journal of Infection·D H GibsonA Baskerville
May 27, 2016·Risk Analysis : an Official Publication of the Society for Risk Analysis·Bidya PrasadCharles N Haas
Jun 10, 2016·Cell Host & Microbe·Gayle M Boxx, Genhong Cheng
Apr 20, 2014·Journal of Pathogens·Dimitra Dimitriadi, Emmanuel Velonakis
Oct 27, 2017·International Journal of Environmental Research and Public Health·Michele TotaroAngelo Baggiani
Oct 30, 2013·Infection and Immunity·Jens JägerMichael Steinert
Feb 10, 2009·International Journal of Experimental Pathology·Mark S LeverAndrew J H Simpson
Feb 6, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Chetan JinadathaWilliam F McCoy
Jun 6, 2018·International Journal of Environmental Research and Public Health·Richard Bentham, Harriet Whiley
Oct 5, 2019·Water·Valerie Madera-GarcíaMarc P Verhougstraete
Oct 1, 2020·International Journal of Environmental Research and Public Health·Michele TotaroAngelo Baggiani
Jul 1, 1994·Infection and Immunity·W S MauchlineC W Keevil
May 1, 1985·Journal of Clinical Microbiology·G E BollinR B Prior
Jun 24, 2021·Journal of Occupational and Environmental Hygiene·Kerry A HamiltonDaniel Gerrity
Jan 11, 2019·Environmental Science & Technology·Kerry A HamiltonP L Gurian

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