Aerosol transmission is an important mode of influenza A virus spread

Nature Communications
B J CowlingJames Mark Simmerman

Abstract

Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness. Here we apply a mathematical model to data from randomized controlled trials of hand hygiene and surgical face masks in Hong Kong and Bangkok households. In these particular environments, inferences on the relative importance of modes of transmission are facilitated by information on the timing of secondary infections and apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We find that aerosol transmission accounts for approximately half of all transmission events. This implies that measures to reduce transmission by contact or large droplets may not be sufficient to control influenza A virus transmission in households.

References

Jul 1, 1979·American Journal of Epidemiology·M R MoserD G Ritter
Jan 1, 1979·Journal of Medical Virology·J W LittleF K Roth
Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·R H AlfordV Knight
Jul 1, 1982·The Journal of Infectious Diseases·B BeanH H Balfour
Jul 1, 1997·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·R S Papineni, F S Rosenthal
Apr 23, 2004·The New England Journal of Medicine·Chad J Roy, Donald K Milton
Feb 8, 2007·Emerging Infectious Diseases·Raymond Tellier
Mar 23, 2007·The Lancet Infectious Diseases·Gabrielle BrankstonMichael Gardam
Jul 17, 2008·PloS One·Patricia FabianDonald K Milton
Oct 14, 2008·The Journal of Infection·Thomas P Weber, Nikolaos I Stilianakis
Jan 13, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Francoise M BlachereDonald H Beezhold
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey Shaman, Melvin Kohn
Aug 5, 2009·Annals of Internal Medicine·Benjamin J CowlingGabriel M Leung
Sep 24, 2009·Journal of the Royal Society, Interface·Raymond Tellier
Oct 1, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James Mark SimmermanTawee Chotpitayasunondh
Oct 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bonnie C K WongIgnatius T S Yu
Dec 15, 2010·PloS One·William G LindsleyDonald H Beezhold
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kortney M GustinTaronna R Maines
Jun 10, 2011·Influenza and Other Respiratory Viruses·James M SimmermanTawee Chotipitayasunondh
Jun 15, 2011·Influenza and Other Respiratory Viruses·Pierre-Yves BoëlleAlain-Jacques Valleron
Jul 30, 2011·The Lancet Infectious Diseases·Ben KillingleyUNKNOWN influenza transmission strategy development group
Jan 24, 2012·American Journal of Infection Control·Dhritiman V MukherjeeElaine L Larson
Mar 23, 2012·PloS One·Peter HorbyJ Kenneth Baillie
Mar 27, 2012·Nature·Aaron R EverittPaul Kellam
Mar 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin J Cowling
Mar 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John D NotiDonald H Beezhold
Dec 12, 2012·Frontiers in Cellular and Infection Microbiology·Donald K Milton
Sep 27, 2013·Influenza and Other Respiratory Viruses·Peter HorbyJohn Kenneth Baillie

❮ Previous
Next ❯

Citations

Jul 30, 2014·Future Virology·Christopher B Brooke
Sep 10, 2014·Advances in Virology·Nikolai NikitinOlga Karpova
Dec 3, 2014·Cell Host & Microbe·Andrew VarbleBenjamin R tenOever
Nov 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis K M IpBenjamin J Cowling
Sep 25, 2015·American Journal of Epidemiology·Cuiling XuBenjamin J Cowling
Jun 9, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Wen-Cheng ChaoChieh-Liang Wu
Jan 1, 2014·Influenza and Other Respiratory Viruses·Peng WuBenjamin J Cowling
Jan 1, 2014·Influenza and Other Respiratory Viruses·Jens W LevyTawee Chotpitayasunondh
Dec 30, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jason S LongWendy S Barclay
Nov 18, 2014·Influenza and Other Respiratory Viruses·Aeron C HurtFrederick G Hayden
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Handel, Pejman Rohani
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Max S Y LauSteven Riley
Dec 20, 2014·Journal of Occupational and Environmental Hygiene·William G LindsleyDonald H Beezhold
Aug 1, 2015·PLoS Computational Biology·Wan YangJeffrey Shaman
Mar 8, 2016·Journal of Occupational and Environmental Hygiene·Blanca PacchaPeter M Rabinowitz
Oct 1, 2014·PloS One·Benjamin J CowlingJ Mark Simmerman
Mar 19, 2016·Influenza and Other Respiratory Viruses·William G LindsleyJohn D Noti
Sep 9, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Jie ZhouHui-Ling Yen
Apr 23, 2015·American Journal of Epidemiology·Ben S CooperAronrag Meeyai
Mar 8, 2017·Nature Communications·Young Soo JoungCullen R Buie
Oct 20, 2017·Emerging Infectious Diseases·Kateri BertranDavid E Swayne
Jun 8, 2018·The Journal of Infectious Diseases·Karen A KormuthLinsey C Marr
Jul 10, 2018·CA: a Cancer Journal for Clinicians·Ella J Ariza-Heredia, Roy F Chemaly
May 6, 2015·Current Epidemiology Reports·Sophia Ng, Aubree Gordon
Sep 20, 2018·Risk Analysis : an Official Publication of the Society for Risk Analysis·Jing YanMatthew Myers
Jan 9, 2015·Theoretical Biology & Medical Modelling·Hiroshi Nishiura, Gerardo Chowell
Oct 12, 2018·Transboundary and Emerging Diseases·Akinlolu JegedeJiewen Guan
Feb 11, 2018·Scientific Reports·David WelchDavid J Brenner
Feb 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sindhu VangetiAnna Smed-Sörensen
Mar 17, 2019·Applied and Environmental Microbiology·Joanna A Pulit-PenalozaTaronna R Maines
Jan 15, 2015·Nature Communications·Young Soo Joung, Cullen R Buie
May 23, 2019·Expert Review of Vaccines·Kylie E C AinslieWalt A Orenstein
Mar 7, 2014·The Journal of Infectious Diseases·Kristin J CummingsDavid N Weissman
Nov 12, 2014·Expert Review of Anti-infective Therapy·Aaron Campigotto, Samira Mubareka
Jun 3, 2016·Epidemiology·Katrin Leitmeyer, Cornelia Adlhoch
Sep 25, 2019·Food and Environmental Virology·Xin ZhaoKongxin Hu
Jun 2, 2020·JAMA : the Journal of the American Medical Association·Edward A Nardell, Ruvandhi R Nathavitharana
Jul 12, 2020·International Forum of Allergy & Rhinology·Michael A KohanskiMichael S Waring

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.