Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury

The Journal of Antimicrobial Chemotherapy
S HashimotoJ Wiener-Kronish

Abstract

Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharmacokinetic/pharmacodynamic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusions of imipenem/cilastatin. The two methods of antibiotic delivery were compared for their effects on bacterial-induced lung injury in rats that had Pseudomonas aeruginosa instilled into their airspaces. The aerosolization of antibiotic was associated with significantly decreased bacterial-induced lung injury. The high concentrations of antibiotic in the airspaces secondary to aerosolization appears to kill bacteria more quickly and preserve lung epithelial and endothelial integrity better than systemic delivery of the same antibiotic.

Citations

Jun 30, 2000·American Journal of Surgery·H C PolkT M McCurry
Mar 25, 2008·Journal of Critical Care·M RadhakrishnanH B Veena Kumari
Jun 18, 2005·Letters in Applied Microbiology·S-W OhD-H Kang
Aug 1, 2005·Journal of Food Protection·Se-Wook OhDong-Hyun Kang
Oct 3, 1999·Antimicrobial Agents and Chemotherapy·E J ErnstJ P Wiener-Kronish
May 27, 2016·Clinical Microbiology Reviews·Eric WenzlerLarry H Danziger

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