PMID: 2117179Jan 1, 1990Paper

Aerosols for systemic treatment

Lung
D Köhler

Abstract

The development of a new group of drugs (polypeptides) have recently increased the interest of alternative administration to the enteral route because of its proteolytic activity and the catabolism of the "first-pass effect." Aside from the "needle," the administration in the respiratory tract via aerosol is the method with the best efficiency. But several problems prohibited its spreading: (1) the accuracy and the reproducibility of the inhaled dose (range ca. 1:4); (2) the small amount of inhaled drug in relation to the dose in the aerosol delivery system (range ca. 1%-10%); (3) the fear of allergic reactions of the respiratory system; (4) the variability of the drug transport into the systemic circulation. New approaches and data raise hopes in reducing the problems: (1) aerosol delivery systems with defined particle spectrum and storage systems; slow vital capacity inhaling maneuver; (2) delivery systems that nebulizes nearly the total amount of drug; (3) all studies with the inhalation application of insulin, heparin, ergotamin, ribavirin, aminoglycosides, and "cigarette smoke" do not reveal any relevant allergic reaction; (4) many studies were performed in the last 10 years on the influence of substances and especially of...Continue Reading

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Citations

May 15, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Magnus DahlbäckBjörn Jonson
Oct 25, 2002·Diabetes Technology & Therapeutics·John ThipphawongStephen J Farr
Sep 11, 2001·American Journal of Therapeutics·V V Ranade
Dec 4, 2003·American Journal of Respiratory and Critical Care Medicine·Andreas GüntherWerner Seeger
Dec 9, 2014·Expert Opinion on Drug Delivery·Jahidur RashidFakhrul Ahsan
Feb 14, 2007·International Journal of Pharmaceutics·Min Jung KwonEun Seong Lee
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiromitsu YamamotoYoshiaki Kawashima
Sep 26, 2006·Advanced Drug Delivery Reviews·Gerhard ScheuchRuediger Siekmeier
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Sep 3, 2005·Cell Death and Differentiation·N FestjensP Vandenabeele
Oct 19, 2021·Chemico-biological Interactions·Dinesh Kumar ChellappanKamal Dua

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