Aerotoxic syndrome, discussion of possible diagnostic criteria

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Gerard HagemanMartin van den Berg

Abstract

Introduction: The term aerotoxic syndrome (ATS) was proposed 20 years ago to describe a constellation of symptoms reported by pilots and cabin crew following exposure to hydraulic fluids, engine oil, and pyrolysis products during flight. Hydraulic fluids and engine oil contain a large number of potentially toxic chemicals, including various organophosphate compounds (OPCs). However, ATS is not yet recognised as a valid diagnosis in aviation or general medicine, because the incidence and aetiology continues to be debated. Discussion: Early studies report findings from symptom surveys or cognitive assessments of small samples of self-selected aircrew, but objective measures of exposure were lacking. Over the last decade, researchers have used more sophisticated techniques to measure exposure, such as on board monitoring studies and biomarkers of exposure (e.g., reduced levels of serum butyrylcholinesterases [BChE]) and more sophisticated techniques to detect nervous system injuries such as fMRI and autoantibody testing. Consideration has also been given to inter-individual differences in the ability to metabolise certain chemical compounds as a result of genetic polymorphisms and exclusion of other potential causes of ill health....Continue Reading

References

Apr 19, 2003·International Journal of Technology Assessment in Health Care·Seems S SonnadRonald D Chervin
Jan 27, 2005·Biochemical Pharmacology·Lucio G CostaClement E Furlong
Apr 6, 2013·Journal of Toxicology and Environmental Health. Part a·Mohamed B Abou-DoniaMichel F A Mulder
May 17, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·G HagemanM van den Berg

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Citations

Mar 16, 2021·Lung·Jorge RoigSusan Michaelis
Aug 19, 2021·Environmental Health : a Global Access Science Source·Susan MichaelisC V Howard

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