Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India

The Indian Journal of Medical Research
Balaji ArvindSushil Kumar Kabra

Abstract

Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables. In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles. Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children. Pseudomonas was the most common bacteria grown in 31 (29.8%) followed by Burkholderia cepacia complex (Bcc) in three (2.8%) patients. Among viruses, Rhinovirus was the most common, identified in 16 (17.4%) samples followed by coronavirus in four (4.3%). Fungi and mycobacteria were isolated from 23 (22.1%) and four (3.8%) children, respectively. Aspergillus flavus was the most common fungus isolated in 13 (12.5%) children...Continue Reading

References

Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·Kenneth N OlivierUNKNOWN Nontuberculous Mycobacteria in Cystic Fibrosis Study Group
Nov 29, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Vishal KapoorVinod Kumar Paul
Jan 13, 2006·BMC Infectious Diseases·Antonietta LambiaseFabio Rossano
Aug 19, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Giuseppe ValenzaMarianne Abele-Horn
Oct 31, 2007·Pediatric Pulmonology·S K KabraS Shastri
Jul 1, 2003·Revista portuguesa de pneumologia·Sofia QuintasCeleste Barreto
May 15, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sandra AsnerDat Tran
Sep 21, 2012·Scandinavian Journal of Infectious Diseases·Rogier A S HoekMenno M van der Eerden
May 15, 2015·Scientific Reports·Bryan CoburnDavid S Guttman
Jun 26, 2015·North American Journal of Medical Sciences·Naveen PatilLeonard N Mukasa
Dec 9, 2015·BMC Pulmonary Medicine·Tania Wrobel FolescuElizabeth Andrade Marques
Jan 1, 2016·PLoS Pathogens·Laura M Filkins, George A O'Toole
Dec 3, 2016·American Journal of Respiratory and Critical Care Medicine·Sarath C RanganathanUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF)
May 4, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Don B SandersUNKNOWN STOP Study Group
Jun 13, 2018·Journal of Tropical Pediatrics·Krishna Mohan GullaSushil K Kabra

❮ Previous
Next ❯

Citations

Jun 26, 2020·Frontiers in Medicine·Sara MantiSalvatore Leonardi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.