Aetiology and outcome of acute and chronic renal failure in infants

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Mirja WedekinLars Pape

Abstract

The aetiology and outcome of acute (ARF) and chronic renal failure (CRF) in infants were analysed in a retrospective study. Between January 1997 and April 2004 all children <1 year of age with a serum creatinine >100 mumol/l at Hannover Medical School were followed up for up to 6 years. One hundred and nineteen children with a serum creatinine >100 mumol/l were identified, 70 infants suffering from ARF and 49 from chronic kidney disease (CKD), stages 3-5. Renal failure was caused in 49/119 (41%) by congenital and in 70/119 (59%) by acquired diseases. The aetiology of ARF (n = 70) included cardiac (27%), prematurity (27%), septic (10%), hepatic (9%), renal (9%) and other (18%) causes. Twelve infants needed transient dialysis treatment. Renal function recovered in all surviving children. The mortality rate was 37%. Causes of death were unrelated to kidney function. Twenty-one of 49 infants with CKD were dialyzed with a median age of 65 days at the start of dialysis, and 23/49 children received a kidney transplant (RTx). The 5-year patient and graft survival for RTx-children of 95.5% was not different from older children. The 5-year patient survival rate of 26 children with CKD without RTx was 63%. The causes of death were parenta...Continue Reading

Citations

Jun 8, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R Todd AlexanderUNKNOWN of the Pediatric Renal Outcomes Group Canada
Mar 11, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katrin MehlerAngela Kribs
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mirja WedekinLars Pape
Aug 27, 2014·Clinics in Perinatology·Joshua J Zaritsky, Bradley A Warady
Jul 19, 2016·Progress in Pediatric Cardiology·Prasad Devarajan, John Lynn Jefferies
Dec 23, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fabio PaglialongaEnrico Verrina
Jan 6, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Hans HartmannLars Pape
Jan 13, 2015·Advances in Chronic Kidney Disease·Patrick D BrophyDavid Askenazi
Oct 14, 2016·Seminars in Fetal & Neonatal Medicine·Jason Misurac
Jul 25, 2019·Transplantation·Luciana S FeltranPaulo Cesar Koch-Nogueira
Mar 18, 2017·Acta Clinica Belgica·Werner KeenswijkJohan VandeWalle
Dec 30, 2017·Pediatric Blood & Cancer·Liezl Du PlessisCherry Mammen
May 28, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jean Grandy, Felipe Veloso

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