Aetiology of bacterial meningitis in infants aged <90 days: Prospective surveillance in Luanda, Angola

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Tuula PelkonenMoe H Kyaw

Abstract

Despite effective antibiotics and vaccines, bacterial meningitis (BM) remains one of the leading causes of morbidity and mortality in young infants worldwide. Data from Africa on the aetiology and antibiotic susceptibility are scarce. To describe the aetiology of BM in Angolan infants <90 days of age. A prospective, observational, single-site study was conducted from February 2016 to October 2017 in the Paediatric Hospital of Luanda. All cerebrospinal fluid samples (CSF) from infants aged <90 days with suspected BM or neonatal sepsis were assessed. The local laboratory performed microscopy, chemistry, culture, and susceptibility testing. PCR for vaccine-preventable pathogens was performed in Johannesburg, South Africa. Of the 1287 infants, 299 (23%) had confirmed or probable BM. Of the 212 (16%) identified bacterial isolates from CSF, the most common were Klebsiella spp (30 cases), Streptococcus pneumoniae (29 cases), Streptococcus agalactiae (20 cases), Escherichia coli (17 cases), and Staphylococcus aureus (11 cases). A fifth of pneumococci (3/14; 21%) showed decreased susceptibility to penicillin, whereas methicillin-resistant S. aureus (MRSA) was encountered in 4/11 cases (36%). Of the gram-negative isolates, 6/45 (13%) wer...Continue Reading

Citations

Mar 31, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tuula PelkonenHeikki Peltola
Jul 9, 2021·International Journal of General Medicine·Yanli LiuZhenlang Lin
Jul 26, 2021·Lancet·Diederik van de BeekEmma C Wall

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International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Tuula PelkonenHeikki Peltola
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