PMID: 8589040Nov 1, 1995Paper

AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer

Genes, Chromosomes & Cancer
V SahaB D Young

Abstract

Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.

References

May 1, 1994·Genes, Chromosomes & Cancer·L P MenasceC J Harrison
Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D NizeticH Lehrach
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J CorralA Karpas
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T NakamuraP C Nowell

❮ Previous
Next ❯

Citations

Jan 14, 2010·Cytogenetic and Genome Research·S S BangaH L Ozer
Dec 6, 2008·International Journal of Cancer. Journal International Du Cancer·Dimitra DafouSimon A Gayther

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.