Affect of Early Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections

Frontiers in Medicine
William DommMichael A O'Reilly

Abstract

Children born preterm often exhibit reduced lung function and increased severity of response to respiratory viruses, suggesting that premature birth has compromised proper development of the respiratory epithelium and innate immune defenses. Increasing evidence suggests that premature birth promotes aberrant lung development likely due to the neonatal oxygen transition occurring before pulmonary development has matured. Given that preterm infants are born at a point of time where their immune system is also still developing, early life oxygen exposure may also be disrupting proper development of innate immunity. Here, we review current literature in hopes of stimulating research that enhances understanding of how the oxygen environment at birth influences lung development and host defense. This knowledge may help identify those children at risk for disease and ideally culminate in the development of novel therapies that improve their health.

References

Feb 1, 1975·Experimental and Molecular Pathology·M J EvansG Freeman
Jun 1, 1990·American Journal of Respiratory Cell and Molecular Biology·M C Williams, L G Dobbs
Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Jan 1, 1996·Annual Review of Physiology·S R Hilfer
Aug 1, 1997·The American Journal of Clinical Nutrition·R K Chandra
Dec 31, 1997·The Pediatric Infectious Disease Journal·W P GlezenP A Piedra
Dec 10, 1999·Pediatric Research·A J Jobe
Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
Jun 15, 2000·Environmental Health Perspectives·K E Pinkerton, J P Joad
Mar 5, 2002·Transgenic Research·Anne-Karina T PerlJeffrey A Whitsett
Jul 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Anne-Karina T PerlJeffrey A Whitsett
Feb 4, 2003·Pediatrics·Lex W DoyleRuth Morley
Mar 4, 2003·Pediatrics·Jonathan M DavisUNKNOWN North American Recombinant Human CuZnSOD Study Group
Oct 3, 2003·Journal of General Internal Medicine·Kristen W SpringerMolly Carnes
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P BallabhS Cunningham-Rundles
Feb 20, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Sandra E JuulRonald J McPherson
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mikhail N MatrosovichHans-Dieter Klenk
Aug 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·K J CollardM W Quinn
Apr 12, 2005·Respiratory Research·Dominik Hartl, Matthias Griese
May 25, 2005·Paediatric Respiratory Reviews·Varinder Singh
Jun 11, 2005·American Journal of Respiratory and Critical Care Medicine·John P KinsellaSteven H Abman
Aug 2, 2005·American Journal of Respiratory Cell and Molecular Biology·Anne-Karina T PerlJeffrey A Whitsett
Aug 16, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard L AutenMary H Whorton
Dec 3, 2005·Pediatrics·Richard A EhrenkranzUNKNOWN National Institutes of Child Health and Human Development Neonatal Research Network
Feb 3, 2006·Pediatrics·Julie A ChoudhuriEric A F Simoes
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Jun 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thai-Yen LingJohn Yu
Jul 25, 2006·Seminars in Perinatology·Patricia R ChessWilliam M Maniscalco
Jul 25, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Min YeeMichael A O'Reilly
Jul 29, 2006·Journal of Virology·Catherine I ThompsonRaymond J Pickles
Oct 3, 2006·The European Respiratory Journal·P N Le Souëf
Jan 9, 2007·Nature Medicine·J M NichollsJ S M Peiris
Jan 24, 2007·Physiological Reviews·Yutaka MaedaJeffrey A Whitsett
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Bernard Thébaud, Steven H Abman
Apr 6, 2007·Pharmacology & Therapeutics·Radhika Kajekar

❮ Previous
Next ❯

Citations

Jan 10, 2017·Journal of Clinical Medicine·Lauren M Davidson, Sara K Berkelhamer
Jan 10, 2017·Disease Models & Mechanisms·Claudio NardielloRory E Morty
Apr 16, 2019·Pediatric Annals·Megan K Tracy, Sara K Berkelhamer
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Dec 19, 2017·The Journal of Allergy and Clinical Immunology·In Su CheonJie Sun
Jun 3, 2021·Vaccines·Ingmar Fortmann On Behalf Of The German Neonatal Network Gnn And The Primal Consortium

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
C VoisinP Sadoul
La Revue du praticien
C Tamalet, J Tamalet
The Journal of Allergy and Clinical Immunology
Mirjami SiltanenErkki Savilahti
© 2021 Meta ULC. All rights reserved