Affected sib-pair analysis of the contribution of HLA class I and class II loci to development of cervical cancer

Human Molecular Genetics
Malin EngelmarkU B Gyllensten

Abstract

Cervical cancer is a multifactorial disease and infection by oncogenic human papilloma viruses represents the main environmental risk factor. Only a subset of infections becomes persistent and develops into cancer, implying that genetic susceptibility factors are needed for malignant progression. Here, we use a population-based cohort of affected sib-pairs (ASPs) to examine the role of the human leukocyte antigen (HLA) class I and class II loci in cervical cancer susceptibility. Analysis of 278 ASPs revealed significant excess genetic sharing for all three HLA class II loci studied, DPB1, DQB1 and DRB1, with the strongest evidence for DQB1 and DRB1. No evidence of excess sharing was observed for the HLA class I HLA-B and HLA-A loci. When the material was stratified on the basis of the DQB1*0602/DRB1*1501 susceptibility haplotype, carriers showed significant sharing for all loci, whereas non-carriers showed no evidence of excess genetic sharing at any of the loci. However, for the DPB1 locus there was no difference in allele frequency between carriers and non-carriers indicating that the effect seen in DPB1 is not simply due to linkage disequilibrium. Our results show that the HLA class II represents a major genetic susceptibili...Continue Reading

Citations

May 15, 2008·European Journal of Human Genetics : EJHG·Asa JohanssonUlf Gyllensten
Mar 14, 2008·Human Molecular Genetics·Valeska B GuzmanAndrey Morgun
Mar 14, 2013·Journal of the National Cancer Institute·Dan ChenUlf Gyllensten
Sep 5, 2013·Infectious Agents and Cancer·Sofía Bernal-SilvaHugo A Barrera-Saldaña
Apr 21, 2009·Future Oncology·Patrícia Savio de Araujo SouzaPaulo Cesar Maciag
Dec 17, 2014·Seminars in Oncology·Harald zur Hausen, Ethel-Michele de Villiers
May 6, 2011·Gynecologic Oncology·Ivana Juko-PecirepUlf B Gyllensten
Jul 10, 2010·Gynecologic Oncology·Shahrzad RahimifarAbbas Ghaderi
Dec 5, 2009·Gynecologic Oncology·Emma L IvanssonUlf B Gyllensten
May 21, 2005·International Journal of Cancer. Journal International Du Cancer·Anna H BeskowUlf B Gyllensten
Jul 9, 2009·International Journal of Cancer. Journal International Du Cancer·Felipe A CastroMichael Pawlita
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Emma L IvanssonPatrik K E Magnusson
Aug 11, 2007·International Journal of Cancer. Journal International Du Cancer·Emma L IvanssonUlf B Gyllensten
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Yuping WuAnlong Xu
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Felipe A CastroMichael Pawlita
Jul 25, 2009·International Journal of Cancer. Journal International Du Cancer·Emma L IvanssonUlf B Gyllensten
Apr 7, 2015·Seminars in Oncology·Harald Zur Hausen, Ethel-Michele de Villiers
Jul 6, 2014·Frontiers in Oncology·Mahboobeh SafaeianMargaret M Madeleine
Apr 3, 2016·International Journal of Cancer. Journal International Du Cancer·Elizabeth A StaigerDouglas F Antczak
Mar 8, 2017·International Journal of Cancer. Journal International Du Cancer·Damayanti Das GhoshSharmila Sengupta
Jul 14, 2018·Omics : a Journal of Integrative Biology·Oppah KuguyoCollet Dandara
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dulce M Hernández-HernándezAlejandro Mohar-Betancourt
Oct 13, 2006·Human Molecular Genetics·Malin T EngelmarkUlf B Gyllensten
Jul 14, 2019·Seminars in Cancer Biology·Balney RajithaGanji Purnachandra Nagaraju
Jan 20, 2021·Veterinary Pathology·Magdalena OgłuszkaAndrzej Raś

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.