Affective instability in those with and without mental disorders: A case control study

Journal of Affective Disorders
S MarwahaM Broome

Abstract

Affective instability (AI) is transdiagnostic, and associated with suicidality and healthcare use. It has rarely been compared between diagnoses or to controls. We investigated: whether AI differs between clinical cases and controls and between diagnoses; how different AI components are correlated; and whether AI is associated with functioning in clinical cases. Cases (N = 69) from psychiatric services had a diagnosis of borderline personality disorder, bipolar disorder, major depression or psychosis and were compared to primary care controls (N = 25). Participants completed the affective lability scale (ALS), affective intensity measure (AIM), affective control scale (ACS), scored mood fluctuation rate and the WHO-DAS. There was a significant difference in affective lability between cases and controls and across diagnostic groups (p < 0.001). Compared to controls, cases showed lower affective control (p < 0.05). There were no differences in affective intensity between cases and controls or between diagnostic groups, or in mood fluctuation rate between groups. ALS score (p < 0.001), and total number of medications (p < 0.046), were associated with functioning, independent of diagnosis. The sample size was modest. Cases were not...Continue Reading

Citations

May 7, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Margrethe Collier HøeghTrine Vik Lagerberg
Oct 22, 2020·International Journal of Molecular Sciences·Laura OrsoliniUmberto Volpe
Dec 31, 2018·Journal of Affective Disorders·Diego A Cornejo-RojasRoger V Araujo-Castillo
Jul 23, 2019·Neuroscience and Biobehavioral Reviews·Elisa BrietzkeClaudio N Soares
Nov 5, 2021·International Journal of Bipolar Disorders·Margrethe Collier HøeghTrine Vik Lagerberg

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