Affective network and default mode network in depressive adolescents with disruptive behaviors

Neuropsychiatric Disease and Treatment
Sun Mi KimDoug Hyun Han

Abstract

Disruptive behaviors are thought to affect the progress of major depressive disorder (MDD) in adolescents. In resting-state functional connectivity (RSFC) studies of MDD, the affective network (limbic network) and the default mode network (DMN) have garnered a great deal of interest. We aimed to investigate RSFC in a sample of treatment-naïve adolescents with MDD and disruptive behaviors. Twenty-two adolescents with MDD and disruptive behaviors (disrup-MDD) and 20 age- and sex-matched healthy control (HC) participants underwent resting-state functional magnetic resonance imaging (fMRI). We used a seed-based correlation approach concerning two brain circuits including the affective network and the DMN, with two seed regions including the bilateral amygdala for the limbic network and the bilateral posterior cingulate cortex (PCC) for the DMN. We also observed a correlation between RSFC and severity of depressive symptoms and disruptive behaviors. The disrup-MDD participants showed lower RSFC from the amygdala to the orbitofrontal cortex and parahippocampal gyrus compared to HC participants. Depression scores in disrup-MDD participants were negatively correlated with RSFC from the amygdala to the right orbitofrontal cortex. The di...Continue Reading

Citations

Oct 28, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Beomwoo NamDoug Hyun Han
Feb 6, 2016·Human Brain Mapping·Harm J van der HornJoukje van der Naalt
Aug 1, 2020·Frontiers in Human Neuroscience·Olga TymofiyevaTony T Yang

❮ Previous
Next ❯

Software Mentioned

PickAtlas

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J N PannekoekN J A van der Wee
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Wen-jing LiuFang Zhang
© 2022 Meta ULC. All rights reserved