Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder

Psychiatry Research
Sophie R DelDonnoScott A Langenecker

Abstract

Anhedonia, the diminished anticipation and pursuit of reward, is a core symptom of major depressive disorder (MDD). Trait behavioral activation (BA), as a proxy for anhedonia, and behavioral inhibition (BI) may moderate the relationship between MDD and reward-seeking. The present studies probed for reward learning deficits, potentially due to aberrant BA and/or BI, in active or remitted MDD individuals compared to healthy controls (HC). Active MDD (Study 1) and remitted MDD (Study 2) participants completed the modified monetary incentive delay task (mMIDT), a behavioral reward-seeking task whose response window parameters were individually titrated to theoretically elicit equivalent accuracy between groups. Participants completed the BI Scale and BA Reward-Responsiveness and Drive Scales. Despite individual titration, active MDD participants won significantly less money than HCs. Higher Reward-Responsiveness scores predicted more won; Drive and BI were not predictive. Remitted MDD participants' performance did not differ from controls', and trait BA and BI measures did not predict r-MDD performance. These results suggest that diminished reward-responsiveness may contribute to decreased motivation and reward pursuit during activ...Continue Reading

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Citations

Feb 6, 2018·Computational Psychiatry·Oliver J Robinson, Henry W Chase
Nov 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefanie Verena MuellerGregor Hasler
Mar 28, 2019·Journal of Clinical and Experimental Neuropsychology·Sophie R DelDonnoScott A Langenecker

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