PMID: 19938537Nov 27, 2009Paper

Affects of different bioreactors in process of Salvia miltiorrhiza adventitious root culture

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Shuo YanYu Cao

Abstract

To study the affects of the different bioreactors on the Salvia miltiorrhiza adventitious root culture. Adventitious roots of S. miltiorrhiza were induced and in vitro cultured in bioreactors. The type of bioreactors was optimized and the kinetics of root growth, accumulation of the active ingredients was also investigated by HPLC. It showed that the 3-1 conical bubble bioreactor (CNBB) with 60 degrees taper favors achieved the highest active compounds accumulation in adventitious roots. The growth curve and secondary metabolites accumulation curve looks like "S" in CNBB bioreactor. The maximum adventitious roots biomass of 16.24 g x L(-1) (fresh weight) was obtained at 35 day. The highest content of tanshinone IIA (TA) and protocatechuic aldehyde (PA) reached 0.23 mg x g(-1) DW and 0.51 mg x g(-1) DW at 40 day, respectively. The 3-1 conical bubble bioreactor (CNBB) with 60 degrees taper favors was the best bioreactors for the accumulation of active compounds.

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