Affiliative behavior requires juvenile, but not adult neurogenesis.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Lan WeiArie Kaffman

Abstract

The capacity to interact with conspecifics is essential for stable social networks, reproduction, and survival in mammals. In rodents, social exploration and play behavior increase during the juvenile period, suggesting that this timeframe represents an important window for socialization. However, the cellular and molecular mechanisms necessary to support this developmental process have not been elucidated. Neurogenesis during the juvenile period, like that in adults, is mainly confined to the subgranular and subventricular zones. Nevertheless, the levels of neurogenesis are significantly higher during the juvenile period, suggesting unique functions not shared with adult neurogenesis. Here we use a transgenic mouse approach that allows for ablation of neurogenesis during different developmental phases. We find that ablating neurogenesis during either juvenile or adult phases altered anxiety and memory in adult female mice, demonstrating an age-independent function of new neurons for certain behaviors. Blocking neurogenesis during the juvenile period resulted in a profound impairment in the ability of these mice to interact with other adult females or to retrieve pups, without causing gross olfactory deficits. Interestingly, ab...Continue Reading

References

Dec 1, 1985·Journal of Comparative Psychology·J C Maggio, G Whitney
Aug 28, 1965·Nature·J Altman, G D Das
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·M E BrewsterN Bodor
Aug 1, 1997·Behavioral Neuroscience·H MaaswinkelB M Spruijt
Apr 15, 1999·Annual Review of Neuroscience·M E Hatten
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·K YamazakiE A Boyse
Apr 5, 2002·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Mar 3, 2004·Behavior Genetics·Norman D HendersonJonathan Flint
Mar 23, 2004·Die Naturwissenschaften·Mathieu BarthelemyGilles Petit
Jun 26, 2004·Annual Review of Neuroscience·Thomas R Insel, Russell D Fernald
Feb 22, 2005·Current Opinion in Neurobiology·Fiona Doetsch, Rene Hen
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Morgane LemassonPierre-Marie Lledo
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanjay S P MagaviJeffrey D Macklis
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mirela CerghetM Said Ghandour
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda S Overstreet-WadicheGary L Westbrook
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D SaxeMichael R Drew
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Maurice A CurtisRichard L M Faull
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary C Whitman, Charles A Greer
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Renata Batista-BritoGord Fishell
Sep 2, 2008·Nature Neuroscience·Itaru ImayoshiRyoichiro Kageyama
Sep 27, 2008·Annual Review of Physiology·Michael J Baum, Kevin R Kelliher
Apr 14, 2009·The Journal of Comparative Neurology·Benjamin H SingerJack M Parent
May 12, 2009·Current Topics in Developmental Biology·Yan LiFred H Gage
Jul 4, 2009·Current Protocols in Neuroscience·Claudia S Caligioni
Nov 26, 2009·Neuroscience and Biobehavioral Reviews·Regina M Sullivan, Parker J Holman
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent Breton-ProvencherArmen Saghatelyan
Feb 16, 2010·Neuron·Michael S Fanselow, Hong-Wei Dong

❮ Previous
Next ❯

Citations

Nov 29, 2012·Nature Neuroscience·Timothy J Schoenfeld, Elizabeth Gould
Sep 3, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Timothy J Schoenfeld, Heather A Cameron
Aug 8, 2014·Molecular and Cellular Endocrinology·David CrewsMichael K Skinner
May 16, 2012·Cellular and Molecular Life Sciences : CMLS·Vanja Duric, Ronald S Duman
Jan 19, 2016·Frontiers in Systems Neuroscience·Sarah HersmanMichael Fanselow
Jul 25, 2012·Hippocampus·Alonso Martinez-CanabalPaul W Frankland
Apr 26, 2015·Behavioural Brain Research·Laurence CoutellierRyan Shepard
Sep 11, 2012·Behavioural Brain Research·Ksenia Z MeyzaRobert J Blanchard
Dec 25, 2012·Neuroscience and Biobehavioral Reviews·Paul WillnerCatherine Belzung
Feb 11, 2014·Brain Structure & Function·Sophie TronelDjoher Nora Abrous
Sep 16, 2014·Frontiers in Behavioral Neuroscience·Greer S KirshenbaumAlex Dranovsky
Jul 12, 2016·Journal of Neuroimmunology·Marilyn S PetroThomas M Petro
Jun 16, 2016·Brain, Behavior, and Immunity·Jean-Christophe DelpechArie Kaffman
Apr 18, 2018·Hippocampus·Rose-Marie KarlssonHeather A Cameron
Aug 30, 2018·Journal of Neuroscience Research·Joanna Medina, Joanna L Workman
Jul 13, 2019·Aging Cell·Danka A KozarevaYvonne M Nolan
Oct 1, 2020·Cellular and Molecular Life Sciences : CMLS·Anne-Kathrin GellnerRené Hurlemann
May 17, 2018·Brain Plasticity·Emily M Jobe, Xinyu Zhao
Jan 18, 2019·International Journal of Molecular Sciences·Carli B JonesCatherine M Davis
Jul 3, 2018·Neurobiology of Learning and Memory·Ana Raquel Pereira-CaixetaGrace S Pereira
Sep 17, 2021·Molecular Psychiatry·Nuria MasachsDjoher Nora Abrous

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.