Affinity liposomes in vivo: factors influencing target accumulation

Journal of Molecular Recognition : JMR
V P Torchilin

Abstract

To make universal and efficient liposome-based drug carriers, liposomes should be able to recognize and bind other targets beyond their natural targets, the cells of the reticuloendothial system. To make liposomes targeted, numerous methods to couple active substances, primarily, monoclonal antibodies, to the liposome surface have been developed. Resulting immunoliposomes (or affinity liposomes) demonstrate good targeting to cells and organs both in vitro and in vivo. However, the short circulation time of immunoliposomes prevented them from accumulating in targets with diminished blood flow or low antigen concentration. Long-circulating liposomes were prepared by coupling soluble and flexible polymers, such as polyethylene glycol, to the liposome surface. The mechanism of liposome steric protection with flexible polymers is based on the formation of dense "conformational cloud' by a grafted polymer over the liposome surface, and might be analyzed in terms of a statistical model of polymer solutions. By co-immobilization of specific antibodies and protecting polymers on the liposome surface, liposomes can be prepared combining both targetability and prolonged circulation in vivo. A biological model (experimental myocardial infa...Continue Reading

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Citations

Sep 1, 1996·Journal of Molecular Recognition : JMR·R Arshady
Dec 18, 2001·Analytical Biochemistry·Melvin E KlegermanDavid D McPherson
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fakhrul AhsanAna I Torres Suarez
Aug 8, 2001·Advanced Drug Delivery Reviews·M A Swartz
Feb 28, 2015·Microscopy Research and Technique·Ana Paula Alves FavaretoIsabel Cristina Cherici Camargo
Jul 2, 2003·Expert Opinion on Biological Therapy·Manohar RatnamXing Pan
Jan 5, 2002·Chemistry : a European Journal·A A YaroslavovF M Menger
May 16, 2014·Nanomedicine·Joana A LoureiroSandra Rocha
Aug 30, 2008·Expert Opinion on Drug Delivery·Vladimir Torchilin
Oct 17, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heegon KimJi-Ho Park
Oct 21, 2016·American Journal of Obstetrics and Gynecology·Jonathan W PaulRoger Smith
Jul 30, 2021·Communications Biology·Timo L M Ten HagenDieter Haemmerich
Jun 28, 2011·Advanced Drug Delivery Reviews·Jennifer D McAllaster, Mark S Cohen

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