PMID: 8964918May 1, 1996Paper

Affinity of anti-GM1 antibodies in Guillain-Barré syndrome patients

Journal of Neuroimmunology
F DeisenhammerE J Thompson

Abstract

In this study, we investigated the affinity of anti-GM1 IgG antibodies as well as their IgG subclass distribution in a series of 38 patients with Guillain-Barré syndrome. In 7 sera elevated titres of IgG anti-GM1 antibodies could be detected. With respect to affinity there were two distinct groups of anti-GM1 antibodies: one group was of high affinity and did not cross-react with other glycolipids; the other group was of low affinity and cross-reacted with asialo-GM1. IgG1 was the predominant and almost exclusive subclass of high affinity anti-GM1 antibodies. Axonal degeneration occurred significantly more frequently in patients with high affinity anti-GM1 antibodies than in patients without anti-GM1 antibodies or in patients with low affinity anti-GM1 antibodies. The presence of anti-Campylobacter jejuni antibodies was not associated with a specific electrophysiological pattern. The prognosis was not dependent on the detection of any of the antibodies, whereas axonal loss and ventilation were associated with a poor prognosis.

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Citations

Oct 17, 1998·Clinical Reviews in Allergy & Immunology·J W TerryberryJ B Peter
Jul 30, 2011·Glycobiology·Aliaksei V PukinHan Zuilhof
Jul 21, 1998·Annals of the New York Academy of Sciences·N BaumannJ M Léger
Sep 13, 2005·Journal of the Neurological Sciences·Mark L KuijfBart C Jacobs
Mar 11, 2005·Journal of Leukocyte Biology·Diego AlignaniMaría C Pistoresi-Palencia
Feb 8, 2020·International Journal of Molecular Sciences·Péter SánthaGábor Jancsó
May 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Astrid ZahnJavier M Di Noia

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