PMID: 3753061Apr 1, 1986Paper

Affinity of antimalarial drugs for stacked haematin linked on sepharose

Annals of Tropical Medicine and Parasitology
S MoreauG Prensier

Abstract

The affinity to haematin of antimalarial drugs and of some closely related compounds has been measured by the use of a polymeric haematin linked to an agarose gel. Haematin-drug interaction shows a low specificity and does not exhibit the sharp structure-activity relationship observed in the biological activities of the compounds. It is suggested that a chloroquine-haematin interaction does not explain the biological properties of this antimalarial, although it constitutes a necessary step in the concentration of the drug in the parasitized erythrocyte.

References

Jan 1, 1976·Bioinorganic Chemistry·J D Stong, C R Hartzell
Jul 1, 1974·The Journal of Clinical Investigation·C D FitchY Gonzalez
May 27, 1967·Nature·P B Macomber, H Sprinz
May 27, 1967·Nature·D C Warhurst, D J Hockley
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·C D Fitch
Jun 30, 1971·Journal of the American Chemical Society·E B FleischerA Chatterjee
Nov 1, 1967·The Biochemical Journal·W A Gallagher, W B Elliott
Oct 31, 1962·Biochemical and Biophysical Research Communications·Y INADA, K SHIBATA
Apr 10, 1965·Acta Crystallographica·D F KOENIG

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.