Affinity of Electrochemically Deposited Sol⁻Gel Silica Films towards Catecholamine Neurotransmitters

Sensors
María Porcel-ValenzuelaFrancisco Montilla

Abstract

Dopamine, norepinephrine, and epinephrine neurotransmitters can be detected by electrochemical oxidation in conventional electrodes. However, their similar chemical structure and electrochemical behavior makes a difficult selective analysis. In the present work, glassy carbon electrodes have been modified with silica layers, which were prepared by electroassisted deposition of sol⁻gel precursors. These layers were morphologically and compositionally characterized using different techniques, such as field emission scanning electron microscopy (FESEM), TEM, FTIR, or thermogravimetric analysis⁻mass spectrometry (TG-MS). The affinity of silica for neurotransmitters was evaluated, exclusively, by means of electrochemical methods. It was demonstrated that silica adsorbs dopamine, norepinephrine, and epinephrine, showing different interaction with silica pores. The adsorption process is dominated by a hydrogen bond between silanol groups located at the silica surface and the amine groups of neurotransmitters. Because of the different interaction with neurotransmitters, electrodes modified with silica films could be used in electrochemical sensors for the selective detection of such molecules.

References

Jan 1, 1976·Journal of Medicinal Chemistry·D C TseR N Adams
Jan 18, 1967·Journal of the American Chemical Society·M D HawleyR N Adams
Nov 1, 1982·Annals of Clinical Biochemistry·R C Causon, M J Brown
Jan 10, 2004·Annals of Clinical Biochemistry·Robert T Peaston, Cyril Weinkove
Mar 12, 2005·Science·Philippe N ToblerWolfram Schultz
Aug 2, 2006·Advances in Colloid and Interface Science·Sudam K ParidaB K Mishra
Jun 26, 2007·Nature Materials·A WalcariusJ Ghanbaja
Jun 26, 2008·Chemical Reviews·Donita L RobinsonR Mark Wightman
Feb 23, 2010·Analytica Chimica Acta·Christopher B JacobsB Jill Venton
Mar 27, 2010·Journal of Chromatography. a·Raluca-Ioana ChiritaClaire Elfakir
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul R BurghardtJon-Kar Zubieta

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