Affymetrix GeneChip system: moving from research to the clinic

Expert Review of Molecular Diagnostics
Jiannis Ragoussis, Gareth Elvidge

Abstract

Affymetrix Inc.'s GeneChip technology has become the industry standard in microarray-based research. Due to the high density of content per array that can be achieved today (an industry leading 6.5 million features) the GeneChips can be used for high-throughput mutation detection, single nucleotide polymorphism genotyping, expression profiling and detection of chromosomal aberrations. This in turn opens the way for clinical applications in genetics, cytogenetics, pharmacogenetics, oncology and pathogen recognition. Establishing standards is a central issue in improving data quality and, in combination with automatic, easy-to-interpret reports, will form the basis of the clinical applicability. Future pricing policies and the resolving of ethical considerations will also dictate the technology's full translation from research into clinical laboratories.

References

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R G SosnowskiM J Heller
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·U A Meyer, U M Zanger
Oct 28, 1997·Archives of Neurology·A D Roses
Nov 3, 2001·Genome Research·D J CutlerA Chakravarti
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Jun 6, 2002·Journal of the National Cancer Institute·David M EuhusGail Tomlinson
Jul 16, 2002·Nature Medicine·David G BeerSamir Hanash
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·James W WilsonCheryl A Nickerson
Oct 17, 2002·Journal of the National Cancer Institute·Valerie BonadonaChristine Lasset
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicole Y FangJoseph G Hacia
Apr 24, 2003·Clinical Chemistry·Maria EraliCarl Wittwer
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerard J NauRichard A Young
Feb 6, 2004·Genome Research·Graham R BignellRichard Wooster
Feb 26, 2004·Nature Genetics·Adrian S IshkanianWan L Lam
Mar 18, 2004·European Journal of Human Genetics : EJHG·Jacqueline SchoumansMagnus Nordenskjöld
May 5, 2004·Genome Research·Anirban MaitraAravinda Chakravarti
Jun 12, 2004·American Journal of Human Genetics·Birgit UhlenbergJutta Gärtner
Jul 9, 2004·Human Molecular Genetics·Stephen J SawcerJonathan L Haines
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Paul GalvinMargarida D Amaral
Dec 14, 2004·Journal of Medical Genetics·A RauchP Nürnberg
Jan 12, 2005·Genome Biology·Michael E ZwickAlfred Mateczun
Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Charles CoxMichael R Stratton
May 28, 2005·Nature Genetics·Ann-Christine Syvänen
Jul 2, 2005·Critical Reviews in Microbiology·Douglas R Call
Sep 6, 2005·Nature Genetics·Anirban MaitraAravinda Chakravarti
Oct 28, 2005·American Journal of Human Genetics·Howard R SlaterGiulia C Kennedy
Dec 16, 2005·Pharmacogenomics·Gareth Elvidge

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Citations

Nov 8, 2007·Analytical and Bioanalytical Chemistry·Frank Dieterle, Estelle Marrer
Oct 2, 2007·Nature Clinical Practice. Rheumatology·Erin J Walker, Katherine A Siminovitch
Dec 16, 2011·Molecular & Cellular Proteomics : MCP·M Pla-RocaD Juncker
Apr 12, 2008·Nucleosides, Nucleotides & Nucleic Acids·Karsten SiegmundClemens Richert
Mar 18, 2008·Applied and Environmental Microbiology·Zhili He, Jizhong Zhou
May 21, 2009·Annual Review of Genomics and Human Genetics·Jiannis Ragoussis
Jul 8, 2009·International Journal of Molecular Sciences·Lu ChengZuhong Lu
Nov 29, 2007·Future Oncology·Noah M HahnChristopher J Sweeney
Apr 10, 2007·Trends in Plant Science·Tong Zhu, John Salmeron
Nov 18, 2006·Biopolymers·Nils G Walter
Jun 22, 2007·Chemical Biology & Drug Design·Estelle Marrer, Frank Dieterle
Jul 1, 2006·Drug Discovery Today. Technologies·Jiannis Ragoussis
Aug 15, 2014·Expert Review of Proteomics·Savita JayaramRavi Sirdeshmukh
Apr 27, 2012·Bioanalysis·Christophe A MarquetteLoïc J Blum

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