Aflatoxin B1 affects apoptosis and expression of Bax, Bcl-2, and Caspase-3 in thymus and bursa of fabricius in broiler chickens

Environmental Toxicology
Xi PengWeimin Lai

Abstract

Aflatoxin B1 is known as a mycotoxin that develops various health problems of animals, the effects of AFB1 on thymus and bursa of Fabricius in chickens are not clear. The objective of this study was to investigate the apoptosis of thymus and bursa of Fabricius in broilers fed with AFB1 . Two hundred Avian broilers were randomly divided into four groups of 50 each, namely control group and three AFB1 groups fed with 0.15 mg, 0.3 mg, and 0.6 mg AFB1 /kg diet, respectively. In this study, flow cytometer and immunohistochemical approaches were used to determine the percentage of apoptotic cells and the expression of Bax, Bcl-2, and Caspase-3. The results showed that consumption of AFB1 diets results in increased percentage of apoptotic cells and increased expression of Caspase-3 in both thymus and bursa of Fabricius. The expression of Bax was increased and the expression of Bcl-2 was decreased in the thymus, but no significant changes in Bax and Bcl-2 expression were observed in the bursa of Fabricius when broilers fed with AFB1 . These findings suggest that adverse effects of AFB1 on thymus and bursa of Fabricius in broilers were confirmed by increased apoptotic cells and abnormal expression of Caspase-3. © 2015 Wiley Periodicals,...Continue Reading

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Citations

Jan 27, 2017·Critical Reviews in Food Science and Nutrition·Shutao YinHongbo Hu
Apr 13, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Wen-Jun WangXiao-Hong Xu
Apr 27, 2017·Seminars in Cancer Biology·Hyun-Jung KimAntoni Barrientos
Jan 9, 2017·Biological Trace Element Research·Muhammad Jameel MughalJing Fang
Dec 29, 2016·Oncotarget·Muhammad Jameel MughalFang Jing
Jul 29, 2015·World Journal of Gastroenterology : WJG·Hai-Bo ZhouZhi-Gang Chen
Aug 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Anna FishbeinDipak Panigrahy
Jan 19, 2017·International Journal of Environmental Research and Public Health·Xi PengKeying Zhang

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