PMID: 5909585Mar 25, 1966

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo

M B SpornG N Wogan


Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.


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