PMID: 5909585Mar 25, 1966

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo

Science
M B SpornG N Wogan

Abstract

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

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Related Concepts

Aflatoxins
Transaminases
Aspergillus
Tumor Promoters
DNA, Double-Stranded
Liver
Nucleosides
RNA
Spectrophotometry
Toxin

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