Aflibercept: A review of its effect on the treatment of exudative age-related macular degeneration

European Journal of Ophthalmology
Zois Papadopoulos

Abstract

Considerable improvement has been achieved in the way in which exudative age-related macular degeneration is conventionally treated and in the associated visual outcomes and prognosis, thanks to the agents with effects against vascular endothelial growth factor (anti-VEGF). By comparison to earlier treatment approaches that involved the use of lasers, the anti-VEGF agents have made it possible to accomplish more positive visual and anatomical outcomes in cases of exudative age-related macular degeneration. Indeed, owing to their positive effects, anti-VEGF agents have quickly come to be considered the gold standard for the treatment of wet age-related macular degeneration. Aflibercept, the most recently approved intravitreally administered anti-VEGF, seems to mark another milestone in the treatment of wet age-related macular degeneration. This anti-VEGF agent presents a series of singular pharmacodynamic and pharmacokinetic attributes that provide it a number of biological benefits in relation to the treatment of choroidal neovascularization compared to other agents. These attributes include high level of affinity for the VEGF-A factor, an intravitreal half-life of great length, as well as the ability to serve as an antagonist ...Continue Reading

References

Feb 4, 2012·Expert Opinion on Pharmacotherapy·Matthew Ohr, Peter K Kaiser
Apr 25, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Daniele VerittiPaolo Lanzetta
Oct 19, 2012·Cell Adhesion & Migration·Johannes M Breuss, Pavel Uhrin
Oct 19, 2012·Cell Adhesion & Migration·Pavel Uhrin, Johannes M Breuss
Oct 23, 2012·Ophthalmology·Jeffrey S HeierUNKNOWN VIEW 1 and VIEW 2 Study Groups
Mar 12, 2013·Expert Review of Clinical Pharmacology·Michael W Stewart
Aug 31, 2013·Drug Design, Development and Therapy·F SemeraroC Costagliola
Oct 5, 2014·Cold Spring Harbor Perspectives in Medicine·Yoshihiro Yonekawa, Ivana K Kim
Mar 15, 2015·Investigative Ophthalmology & Visual Science·Massimo Dal MontePaola Bagnoli
Jun 17, 2015·Expert Opinion on Biological Therapy·Mohammad Hossein YazdiMohammad Abdollahi
Oct 8, 2015·Drugs & Aging·Alfredo García-LayanaNicholas Reiter
Oct 13, 2015·Korean Journal of Ophthalmology : KJO·Ju Young KimSoon Hyun Kim
Nov 19, 2015·Science Signaling·Stéphanie HerkenneIngrid Struman
Mar 5, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arshad M KhananiRezi Zawadzki
Mar 17, 2016·Expert Opinion on Biological Therapy·Muhammad HassanQuan Dong Nguyen
May 12, 2016·Investigative Ophthalmology & Visual Science·Maurizio CammalleriPaola Bagnoli
Oct 27, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hui KimChul Gu Kim
Nov 12, 2016·Central-European Journal of Immunology·Dorota Pożarowska, Piotr Pożarowski
Dec 3, 2016·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Helena Giannakaki-ZimmermannMartin S Zinkernagel
Dec 13, 2017·Retina·João R de Oliveira DiasEduardo B Rodrigues

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Software Mentioned

ASSESS
VIEW
UPARANT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.