Aflibercept therapy for polypoidal choroidal vasculopathy: short-term results of a multicentre study

The British Journal of Ophthalmology
Hideki KoizumiTomohiro Iida

Abstract

To investigate short-term outcomes of intravitreal aflibercept injections (IAIs) for polypoidal choroidal vasculopathy (PCV). 91 eyes of 88 consecutive patients with treatment-naive PCV examined at three university hospitals received IAI monthly for 3 months. One month after the third IAI, changes in best-corrected visual acuity (BCVA) and macular morphology were retrospectively evaluated. Additionally, possible baseline characteristics predictive of persistent retinal fluid were analysed. The mean BCVA (logarithm of the minimum angle of resolution units) of the 91 eyes improved from 0.31 at baseline to 0.21 at 3 months (p<0.0001). The mean central retinal thickness and mean subfoveal choroidal thickness decreased from 323 μm and 270 μm at baseline to 185 μm and 232 μm at 3 months, respectively (p<0.0001 for both). Seventy-three eyes (80.2%) achieved a dry macula defined as absence of retinal fluid. Presence of the baseline characteristics of subretinal haemorrhage and greater size of the largest polyp were significantly associated with inability to achieve a dry macula (p=0.008 and 0.03, respectively). However, this association was not found on multivariate logistic regression. Of the 90 eyes that underwent indocyanine green a...Continue Reading

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Citations

Oct 3, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Colin S TanSeenu M Hariprasad
Feb 28, 2016·American Journal of Ophthalmology·Han Joo ChoJong Woo Kim
Jun 20, 2015·Ophthalmology·Akiko YamamotoTomohiro Iida
Aug 20, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kei TakayamaHiroko Terasaki
Sep 24, 2016·Japanese Journal of Ophthalmology·Masaaki SaitoTetsuju Sekiryu
Dec 16, 2016·The British Journal of Ophthalmology·Erina DaizumotoTaiji Sakamoto
Apr 7, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jae Hui KimJong Woo Kim
Feb 27, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Han Joo ChoJong Woo Kim
Jul 3, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masahiro MorimotoHideo Akiyama
Jan 9, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Young Ho KimJaeryung Oh

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