AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane

Biochimica Et Biophysica Acta
Z LeonenkoD Cramb

Abstract

In spite of numerous investigations, the molecular mechanism of general anesthetics action is still not well understood. It has been shown that the anesthetic potency is related to the ability of an anesthetic to partition into the membrane. We have investigated changes in structure, dynamics and forces of interaction in supported dipalmitoylphosphatidylcholine (DPPC) bilayers in the presence of the general anesthetic halothane. In the present study, we measured the forces of interaction between the probe and the bilayer using an atomic force microscope. The changes in force curves as a function of anesthetic incorporation were analyzed. Force measurements were in good agreement with AFM imaging data, and provided valuable information on bilayer thickness, structural transitions, and halothane-induced changes in electrostatic and adhesive properties.

References

Sep 15, 1995·Physical Review. B, Condensed Matter·J P ClevelandP K Hansma
Mar 30, 2000·Journal of Microbiological Methods·H H FangL C Xu
Apr 20, 2002·Biophysical Journal·Emilios K DimitriadisRichard S Chadwick
Oct 9, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hans-Jürgen Butt, Volker Franz
Oct 9, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Simona LoiHans-Jürgen Butt

❮ Previous
Next ❯

Citations

Sep 13, 2012·Analytical and Bioanalytical Chemistry·Sandrine MorandatKarim El Kirat
Dec 4, 2012·Chemistry and Physics of Lipids·David E LeeDixon J Woodbury
Nov 21, 2009·Chemistry and Physics of Lipids·Matthew R NussioJoseph G Shapter
Nov 18, 2008·Biophysical Chemistry·G S LoriteM A Cotta
Jul 6, 2007·Chemistry : a European Journal·Xiaojun HanStephen D Evans
Mar 17, 2010·Microscopy Research and Technique·C CanaleS Dante
Sep 30, 2008·Biochimica Et Biophysica Acta·Emel I GoksuMarjorie L Longo
Feb 14, 2012·Biophysical Journal·Juan M VanegasMarjorie L Longo
Oct 20, 2010·Biochimica Et Biophysica Acta·Joaquim T MarquêsRodrigo F M De Almeida
Oct 3, 2009·Biochimica Et Biophysica Acta·Marie-Cécile GiocondiChristian Le Grimellec
Aug 12, 2009·Biochimica Et Biophysica Acta·Karim El KiratYves F Dufrêne
Jun 21, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Lia M C LimaFausto Sanz
Jun 5, 2012·The Journal of Physical Chemistry. B·Racha El ZeinAnne M Charrier
Aug 5, 2014·Soft Matter·Andrea Alessandrini, Paolo Facci
Feb 8, 2013·International Journal of Molecular Sciences·Simon J AttwoodZoya Leonenko
Oct 5, 2018·The Journal of Membrane Biology·Felipe de Sá RochaCésar Augusto Souza de Andrade
Jun 10, 2020·Journal of Molecular Modeling·Bin XieRunguang Sun
Apr 24, 2010·The Journal of Physical Chemistry. B·Julia O SubbotinaSergei Yu Noskov
Dec 20, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Matthew R NussioJoseph G Shapter
Jul 4, 2009·The Journal of Physical Chemistry. B·Matthew R NussioNicolas H Voelcker
Jun 4, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Juan M VanegasMarjorie L Longo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.