AFM study of the elastin-like biopolymer poly(ValGlyGlyValGly)

Biomacromolecules
Roberta FlamiaAntonio M Tamburro

Abstract

In this paper, we report an AFM study on the supramolecular structures adopted by the synthetic polypentapeptide poly(ValGlyGlyValGly), whose monomeric sequence is an abundant, simple building block of elastin. The polypeptide was analyzed by deposition from both methanolic and aqueous suspensions, showing different behaviors. In methanol, the polypeptide is able to evolve, in a time-dependent way, from layers to ribbons to beaded filaments. When the equilibrium is reached, the formation of well-defined dendritic structures is also observed. This restructuring of the polypentapeptide seems to be reminiscent of a sort of Rayleigh instability. When deposited from aqueous suspensions, the polypeptide self-assembles either in fibrillar networks or in amyloid-like patterns, both of them being found in elastin or elastin-related polypeptides. As a general finding, poly(ValGlyGlyValGly) seems to constitute an excellent mimetic of the supramolecular properties of native elastin.

References

Nov 1, 1978·Journal of Ultrastructure Research·A Serafini-FracassiniJ Hinnie
Dec 1, 1992·Journal of Biomolecular Structure & Dynamics·A M TamburroD D Gordini
Mar 1, 1990·Biopolymers·V GuantieriA M Tamburro
Mar 1, 1986·Journal of Ultrastructure and Molecular Structure Research·G M BressanD Volpin
Jan 1, 1974·Journal of Ultrastructure Research·L GotteR W Horne
Jun 1, 1995·Journal of Biomolecular Structure & Dynamics·A M TamburroL D'Alessio
Jan 1, 1994·Micron : the International Research and Review Journal for Microscopy·E MothesP Traub
Aug 1, 1993·Journal of Biomolecular Structure & Dynamics·M A MorelliA M Tamburro
Jun 10, 1998·Journal of Biomolecular Structure & Dynamics·M MartinoA M Tamburro
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L Debelle, A M Tamburro
Mar 8, 2000·International Journal of Biological Macromolecules·M MartinoA M Tamburro
Mar 11, 2003·The Journal of Biological Chemistry·Beth A KozelRobert P Mecham

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Citations

Jun 23, 2006·Biotechnology Letters·F Javier AriasJ Carlos Rodríguez-Cabello
Jun 29, 2011·Biomacromolecules·Angelo BracalelloAntonietta Pepe
Dec 20, 2011·Biomacromolecules·Anton P Le BrunMichael James
Nov 19, 2009·Journal of the American Chemical Society·Younhee ChoPaul S Cremer
Oct 10, 2008·The Journal of Physical Chemistry. B·Younhee ChoPaul S Cremer
Aug 25, 2007·Nanomedicine·Antonietta PepeAntonio M Tamburro
Dec 20, 2008·Nanomedicine·Brigida BochicchioAntonio Mario Tamburro
Jun 10, 2009·Nanomedicine·Antonio M Tamburro
Apr 5, 2014·World Journal of Microbiology & Biotechnology·Tomasz KowalczykAndrzej K Kononowicz
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Loretta Laureana Del MercatoRoss Rinaldi
Apr 2, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Pasquale MoscarelliDaniela Quaglino
Mar 17, 2015·Advanced Healthcare Materials·Giselle C YeoAnthony S Weiss
Dec 3, 2011·Chirality·Brigida Bochicchio, Antonietta Pepe
Nov 3, 2010·Chirality·Antonio Mario TamburroBrigida Bochicchio
Nov 18, 2010·Advances in Colloid and Interface Science·Giselle C YeoAnthony S Weiss
May 3, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Antonietta PepeAntonio M Tamburro
Mar 27, 2015·Soft Matter·Brigida BochicchioManuel Dauchez
Nov 20, 2004·The Journal of Biological Chemistry·Antonio Mario TamburroIvonne Pasquali Ronchetti
Sep 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sean O'Neill MooreChandrasekhar R Kothapalli
Nov 20, 2019·Nanomaterials·Angelo BracalelloChiara Battocchio
Jul 7, 2018·Analytical and Bioanalytical Chemistry·Maria Elvira CarboneAnna Maria Salvi
Sep 18, 2020·International Journal of Molecular Sciences·Maria Rita CiteroniBarbara Barboni
Mar 21, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S MarchettiA Toscano
Aug 19, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Nadia TzokovaDave J Adams
Jan 24, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Nadia TzokovaAnthony J Ryan
May 2, 2020·The Journal of Physical Chemistry Letters·Jingqiang LiChing-Hwa Kiang
May 8, 2017·ACS Biomaterials Science & Engineering·Lisa D Muiznieks, Fred W Keeley

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