Afobazole protects rats exposed to peat smoke in utero

Bulletin of Experimental Biology and Medicine
D M GorbatovaS B Seredenin

Abstract

Female outbred albino rats were daily subjected to forced inhalations of peat smoke (4 cores packed with a mixture of peat (70%) and wood pulp (30%); 0.46 g, pH at least 5.5, core burning time 6 min,; total exposure 44 min) per se and in combination with oral afobazole (anxiolytic) in doses of 1 and 10 mg/kg on days 1-20 of pregnancy. Some groups of females received oral afobazole (200 mg/kg) after delivery, due to which their newborn rats received the drug in doses of 1-10 mg/kg with maternal milk on days 1-20 of life. Exposure to peat smoke inhibited body weight gain in the progeny on days 5-60 of life. Afobazole treatment during the pre- and postnatal periods prevented this effect. Open field testing showed that exposure to peat smoke prolonged the motor activity in the progeny and impaired the loss of orientation and exploratory behavior during repeated testing. Oral afobazole (1 and 10 mg/kg) during the prenatal and/or postnatal period (with maternal milk) prevented the effects of peat smoke.

References

Feb 24, 2007·Neuroscience and Biobehavioral Reviews·Michael A van der Kooij, Jeffrey C Glennon
Dec 27, 2008·Bulletin of Experimental Biology and Medicine·O V ShrederS B Seredenin
Mar 11, 2010·Current Opinion in Pediatrics·Donald R Mattison
Sep 3, 2010·Behavioral and Brain Functions : BBF·Yu QianRochellys Diaz Heijtz
Jan 20, 2011·Bulletin of Experimental Biology and Medicine·A D DurnevS B Seredenin

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