AFP-producing squamous cell carcinoma of the lung in an adolescent

Japanese Journal of Clinical Oncology
H AsamuraT Naruke

Abstract

We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alphafetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.

Citations

May 11, 2011·World Journal of Surgical Oncology·Masahiro KitadaTadahiro Sasajima
Aug 30, 2008·Cases Journal·Jeff F WangDeba P Sarma
Jan 11, 2014·Journal of Gastrointestinal Cancer·Walid ShaibBassel El Rayes
Jul 20, 2016·QJM : Monthly Journal of the Association of Physicians·G-Q QianJ-G Chu
Apr 10, 2002·Pathology International·Kenzo HiroshimaHidemi Ohwada
Mar 2, 2006·International Journal of Clinical Oncology·Hiroyasu NagakawaTakayuki Kuriyama
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Dec 31, 2016·QJM : Monthly Journal of the Association of Physicians·Min LiuLihua Dong
Feb 24, 2001·Pediatric Hematology and Oncology·D T SchneiderU Göbel

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