PMID: 9174158May 1, 1997Paper

African-American HLA class II allele and haplotype diversity

Tissue Antigens
J J JustW Klitz

Abstract

Molecular genetic techniques were used to type nine loci in the HLA class II region in 241 unrelated African-Americans from New York City (NYC). Several effects attributable to recent genetic admixture were evident: the number of distinct class II alleles and haplotypes was larger in the African-Americans than in people of African or European origin, the allele frequencies were more consistently even, and linkage disequilibrium was present across the entire class II region. The African-American DRB1 allele frequencies almost always fell between frequencies among samples from northern Europe and the Gambia, two possible founding populations. The exceptions are attributed to the contribution of other genetically dissimilar African groups to the African-American gene pool. DRB1 allele frequencies (specifically DRB1*1501) and some haplotypes of DRB1-DPB1 were different in our NYC and the 11th International Histocompatibility Workshop (IHW) samples of African-Americans. The high level of allele and haplotype diversity found in African-Americans has important implications for the construction of pools of unrelated potential donors for tissue transplantation.

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Citations

Oct 3, 2001·Tissue Antigens·N PimtanothaiA H Johnson
May 4, 2007·Genes and Immunity·B A RybickiUNKNOWN SAGA Study Consortium
May 23, 2008·Sexually Transmitted Diseases·William M GeislerRichard A Kaslow
Jun 30, 2001·Journal of Neuroimmunology·L LinE Mignot
Oct 7, 2010·Immunological Investigations·Carlos SilveraAntonio Arnaiz-Villena
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chengbin WangRichard A Kaslow
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Sep 26, 2003·American Journal of Human Genetics·Milton D RossmanUNKNOWN ACCESS Group
Dec 12, 2003·American Journal of Human Genetics·Jorge R OksenbergStephen L Hauser
Feb 14, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J M HewardA H Barnett
Oct 8, 1999·Emerging Infectious Diseases·L LouieW Klitz
Sep 3, 2013·Transplantation·Anat R TamburJohn J Friedewald
Jan 17, 2002·Genetic Epidemiology·J GrigullA D Paterson
Aug 29, 2006·Arquivos brasileiros de endocrinologia e metabologia·Crésio AlvesDenise LeMaire
Jan 30, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Scott R SolomonAsad Bashey

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