African-American Men with Gleason Score 3+3=6 Prostate Cancer Produce Less Prostate Specific Antigen than Caucasian Men: A Potential Impact on Active Surveillance

The Journal of Urology
Oleksandr N KryvenkoJonathan I Epstein

Abstract

We assess the difference in prostate specific antigen production between African-American and Caucasian men with Gleason score 3+3=6 prostate cancer. We measured tumor volume in 414 consecutive radical prostatectomies from men with National Comprehensive Cancer Network(®) low risk prostate cancer (348 Caucasian, 66 African-American) who had Gleason score 3+3=6 disease at radical prostatectomy. We then compared clinical presentation, pathological findings, prostate specific antigen, prostate specific antigen density and prostate specific antigen mass (an absolute amount of prostate specific antigen in patient's circulation) between African-American and Caucasian men. The t-test and Wilcoxon rank sum were used for comparison of means. African-American and Caucasian men had similar clinical findings based on age, body mass index and prostate specific antigen. There were no statistically significant differences between the dominant tumor nodule volume and total tumor volume (mean 0.712 vs 0.665 cm(3), p=0.695) between African-American and Caucasian men. Prostates were heavier in African-American men (mean 55.4 vs 46.3 gm, p <0.03). Despite the significantly greater weight of benign prostate tissue contributing to prostate specific ...Continue Reading

References

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Apr 26, 2012·The American Journal of Surgical Pathology·Hillary M RossJonathan I Epstein
May 11, 2013·The Journal of Urology·H Ballentine CarterAnthony L Zietman
Apr 1, 2014·Urology·Oleksandr N KryvenkoJonathan I Epstein
Aug 27, 2015·International Journal of Surgical Pathology·George A TjionasOleksandr N Kryvenko

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Citations

May 12, 2016·BMC Urology·Divya ShenoySrinivasan Vijayakumar
Dec 18, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ganesh M BabulalUNKNOWN International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association
May 10, 2016·The American Journal of Surgical Pathology·Oleksandr N KryvenkoMerce Jorda
Nov 15, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Nagi B KumarCatherine M Phelan
Aug 16, 2017·Current Urology Reports·Zachary L SmithAdam B Murphy
Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero

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