African American Participation in Oncology Clinical Trials--Focus on Prostate Cancer: Implications, Barriers, and Potential Solutions

Clinical Genitourinary Cancer
Chiledum AhaghotuOliver Sartor

Abstract

In the United States, the incidence and mortality rates of many cancers, especially prostate cancer, are disproportionately high among African American men compared with Caucasian men. Recently, mortality rates for prostate cancer have declined more rapidly in African American versus Caucasian men, but prostate cancer is still the most common cancer and the second leading cause of cancer deaths in African American men in the United States. Compared with Caucasian men, prostate cancer occurs at younger ages, has a higher stage at diagnosis, and is more likely to progress after definitive treatments in African American men. Reasons for racial discrepancies in cancer are multifactorial and potentially include socioeconomic, cultural, nutritional, and biologic elements. In addition to improving access to novel therapies, clinical trial participation is essential to adequately establish the risks and benefits of treatments in African American populations. Considering the disproportionately high mortality rates noted in these groups, our understanding of the natural history and responses to therapies is limited. This review will explore African American underrepresentation in clinical trials with a focus on prostate cancer, and poten...Continue Reading

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Citations

Apr 25, 2017·Cancer·Lauren P Wallner, Steven J Jacobsen
Feb 23, 2020·Journal of Racial and Ethnic Health Disparities·Kyle B ZunigaStacey A Kenfield
Mar 1, 2020·Prostate Cancer and Prostatic Diseases·Oliver SartorCelestia S Higano
Jul 13, 2020·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Mohammed AlhajjiLinda Fleisher

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