African ancestry and lung function in Puerto Rican children.

The Journal of Allergy and Clinical Immunology
John M BrehmJuan C Celedón

Abstract

Puerto Rican and African American subjects share a significant proportion of African ancestry. Recent findings suggest that African ancestry influences lung function in African American adults. We sought to examine whether a greater proportion of African ancestry is associated with lower FEV(1) and forced vital capacity (FVC) in Puerto Rican children independently of socioeconomic status, health care access, or key environmental/lifestyle factors. We performed a cross-sectional case-control study of 943 Puerto Rican children aged 6 to 14 years with (n= 520) and without (n= 423) asthma (defined as physician-diagnosed asthma and wheeze in the prior year) living in Hartford, Connecticut (n= 383), and San Juan, Puerto Rico (n= 560). We estimated the percentage of African racial ancestry in study participants using genome-wide genotypic data. We tested whether African ancestry is associated with FEV(1) and FVC using linear regression. Multivariate models were adjusted for indicators of socioeconomic status and health care and selected environmental/lifestyle exposures. After adjustment for household income and other covariates, each 20% increment in African ancestry was significantly associated with lower prebronchodilator FEV(1) (-...Continue Reading

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Citations

May 17, 2012·American Journal of Respiratory and Critical Care Medicine·Erick Forno, Juan C Celedón
Jun 2, 2012·American Journal of Respiratory and Critical Care Medicine·John M BrehmJuan C Celedón
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Wei ChenJuan C Celedón
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·Joe G N Garcia, Jacob I Sznajder
Apr 1, 2014·Paediatric Respiratory Reviews·Janet StocksSooky Lum
Oct 22, 2013·The Journal of Allergy and Clinical Immunology·Christian Rosas-SalazarJuan C Celedón
Jun 25, 2015·Thorax·Erick FornoJuan C Celedón
Apr 29, 2015·The Journal of Allergy and Clinical Immunology·Joanne E SordilloAugusto A Litonjua
Oct 21, 2015·Frontiers in Genetics·Tesfaye B Mersha
Sep 1, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yueh-Ying HanJuan C Celedón
Aug 8, 2014·Pediatric Pulmonology·Christian Rosas-SalazarJuan C Celedón
Sep 2, 2015·American Journal of Respiratory and Critical Care Medicine·John M BrehmJuan C Celedón
Jun 9, 2015·Respiratory Medicine·Sima K RamratnamJuan C Celedón
Apr 29, 2015·American Journal of Respiratory and Critical Care Medicine·John M BrehmJuan C Celedón
Dec 3, 2013·The Journal of Allergy and Clinical Immunology·Erick FornoJuan C Celedón
Dec 4, 2012·The Journal of Allergy and Clinical Immunology·Stanley J Szefler
Dec 29, 2013·The Journal of Allergy and Clinical Immunology·Victor E Ortega, Deborah A Meyers
Jan 27, 2015·The Journal of Allergy and Clinical Immunology·Corinne A KeetElizabeth C Matsui
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Jun 3, 2014·American Journal of Respiratory and Critical Care Medicine·Franziska J RosserJuan C Celedón
Nov 21, 2014·American Journal of Respiratory and Critical Care Medicine·Samatha SonnappaJanet Stocks
Jun 2, 2016·The Journal of Allergy and Clinical Immunology·Sze Man TseDiane R Gold
Jul 10, 2016·Current Allergy and Asthma Reports·Natalia Hernandez-PachecoMaria Pino-Yanes
Oct 19, 2016·The Journal of Allergy and Clinical Immunology·Sylvia E SzentpeteryJuan C Celedón
Aug 27, 2016·American Journal of Respiratory and Critical Care Medicine·Michele AriglianiPhilip H Quanjer
Feb 9, 2017·The Journal of Allergy and Clinical Immunology·Erick FornoJuan C Celedón
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Jan 11, 2017·The Journal of Allergy and Clinical Immunology·Wei ChenJuan C Celedón
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Dec 28, 2017·Pediatric Allergy, Immunology, and Pulmonology·Yueh-Ying HanJuan C Celedón
Oct 24, 2015·The European Respiratory Journal·Sooky LumJanet Stocks
Jun 2, 2015·The European Respiratory Journal·Philip H Quanjer
May 4, 2017·The European Respiratory Journal·Qi YanJuan C Celedón
Mar 30, 2019·The European Respiratory Journal·Yale JiangJuan C Celedón
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