African Lungfish Reveal the Evolutionary Origins of Organized Mucosal Lymphoid Tissue in Vertebrates

Current Biology : CB
Luca TacchiIrene Salinas

Abstract

One of the most remarkable innovations of the vertebrate adaptive immune system is the progressive organization of the lymphoid tissues that leads to increased efficiency of immune surveillance and cell interactions. The mucosal immune system of endotherms has evolved organized secondary mucosal lymphoid tissues (O-MALT) such as Peyer's patches, tonsils, and adenoids. Primitive semi-organized lymphoid nodules or aggregates (LAs) were found in the mucosa of anuran amphibians, suggesting that O-MALT evolved from amphibian LAs ∼250 million years ago. This study shows for the first time the presence of O-MALT in the mucosa of the African lungfish, an extant representative of the closest ancestral lineage to all tetrapods. Lungfish LAs are lymphocyte-rich structures associated with a modified covering epithelium and express all IGH genes except for IGHW2L. In response to infection, nasal LAs doubled their size and increased the expression of CD3 and IGH transcripts. Additionally, de novo organogenesis of inducible LAs resembling mammalian tertiary lymphoid structures was observed. Using deep-sequencing transcriptomes, we identified several members of the tumor necrosis factor (TNF) superfamily, and subsequent phylogenetic analyses r...Continue Reading

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Oct 23, 2014·Nature Communications·Luca TacchiIrene Salinas

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Citations

Sep 24, 2015·Molecular Immunology·Ali Sepahi, Irene Salinas
Mar 21, 2018·Nature Reviews. Immunology·Martin F Flajnik
May 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoki MaedaToshiaki Miyadai
Oct 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei-Guang KongZhen Xu
Apr 3, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D HeimrothIrene Salinas
Dec 6, 2017·FEMS Microbiology Ecology·Irene de BruijnJos M Raaijmakers
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Cynthia Arroyo PortillaHugues Lelouard
Dec 5, 2018·Developmental and Comparative Immunology·Elisa Casadei, Irene Salinas

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