PMID: 9557723Apr 29, 1998Paper

African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies

Journal of Virology
A M VandammeP Goubau

Abstract

We identified a potential new subtype within human T-cell lymphotropic virus type 2 (HTLV-2), HTLV-2d, present in members of an isolated Efe Bambuti Pygmy tribe. Two of 23 Efe Pygmies were HTLV-2 seropositive, with HTLV-2 Western blot and enzyme-linked immunosorbent assay reactivities. From one of them the entire genome of the HTLV-2 strain Efe2 could be amplified and sequenced. In all gene regions analyzed, this strain was the most divergent HTLV-2 strain, differing by 2.4% (tax/rex) to 10.7% (long terminal repeat) from both subtypes HTLV-2a and HTLV-2b, yet major functional elements are conserved. The similarity between the HTLV-2 Efe2 Gag and Env proteins and the corresponding HTLV-2a and -2b proteins is consistent with the observed serological reactivity. In the proximal pX region, one of the two alternative splice acceptor sites is abolished in HTLV-2 Efe2. Another interesting feature of this potential new subtype is that it has a Tax protein of 344 amino acids (aa), which is intermediate in length between the HTLV-2a Tax protein (331 aa) and the HTLV-2b and -2c Tax proteins (356 aa) and similar to the simian T-cell lymphotropic virus type 2 (STLV-2) PP1664 Tax protein. Together these two findings suggest a different pheno...Continue Reading

References

Apr 1, 1992·Journal of Virology·W W HallR C Gallo
Sep 17, 1992·Nature·P GoubauB Kasereka
Jul 1, 1992·The Journal of Infectious Diseases·E M MaloneyW A Blattner
Sep 1, 1990·Lancet·D ZellaU Bertazzoni
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K ShimotohnoT Sugimura
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N SagataY Ikawa
Jan 1, 1986·Progress in Nucleic Acid Research and Molecular Biology·C Weissmann, H Weber
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Aug 1, 1995·AIDS Research and Human Retroviruses·P MauclereA Gessain
May 1, 1995·AIDS Research and Human Retroviruses·Y FukushimaT Ngoc Trinh
Nov 15, 1995·International Journal of Cancer. Journal International Du Cancer·A BazarbachiF Galibert
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M SalemiU Bertazzoni
Oct 1, 1993·AIDS Research and Human Retroviruses·T IgarashiM Hayami
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·P GoubauJ Desmyter
Aug 1, 1993·AIDS Research and Human Retroviruses·A FromentB Larouzé
Aug 1, 1993·AIDS Research and Human Retroviruses·P GoubauJ Desmyter
Aug 1, 1993·AIDS Research and Human Retroviruses·H TakahashiW W Hall

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Citations

Nov 18, 2000·AIDS Research and Human Retroviruses·R MahieuxJ N Brady
Sep 16, 2003·Cadernos de saúde pública·Ricardo IshakMarluísa de Oliveira Guimarães Ishak
Apr 21, 2006·AIDS Research and Human Retroviruses·Jane Dagmar Pollo RennerVirgínia Minghelli Schmitt
Sep 8, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Helena Kaminami MorimotoAdele Caterino-de-Araujo
Jun 23, 2010·Archives of Gynecology and Obstetrics·Ioannis MylonasKlaus Friese
Apr 5, 2011·The Journal of Infectious Diseases·Philippe MauclèreAntoine Gessain
Mar 15, 2013·AIDS Research and Human Retroviruses·Mariana Cavalheiro MagriAdele Caterino-de-Araujo
May 24, 2019·BMC Infectious Diseases·Isabel Luís Jocene BraçoAntonio Carlos Rosário Vallinoto
Feb 16, 2020·Retrovirology·Ricardo IshakAntonio Carlos R Vallinoto
Oct 12, 2010·AIDS Research and Human Retroviruses·Filipe Ferreira de Almeida RegoLuiz Carlos Alcantara
Sep 22, 2010·AIDS Research and Human Retroviruses·María AbadAlejandro Vallejo
Sep 19, 2003·AIDS Research and Human Retroviruses·Dimas Tadeu Covas, Simone Kashima
Dec 20, 2005·The Journal of Pathology·Ruth F Jarrett
Nov 26, 2011·AIDS Research and Human Retroviruses·Carolina A BeriniMirna M Biglione
Oct 25, 2016·Virus Evolution·Steve Ahuka-MundekeAhidjo Ayouba
May 29, 2015·Journal of Virology·Beatrix KapusinszkyEric Delwart
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SalemiA M Vandamme
Aug 9, 2019·Retrovirology·Michael P MartinezPatrick L Green
May 30, 2006·Virus Genes·Kathleen Margaret McGirr, Gertrude Case Buehuring
Sep 15, 2005·Molecular Ecology·Thierry WirthMark Achtman
Nov 19, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Gemilson Soares PontesAntonio Carlos Rosário Vallinoto
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Carolina RosadasRicardo Ishak
Jan 10, 2002·Journal of Medical Virology·Edimilson A SilvaAna Carolina P Vicente
Dec 17, 1998·Journal of Clinical Microbiology·W V BoltonN K Saksena
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Carolina RosadasRicardo Ishak
Jul 14, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Carlos BritesAntonio Carlos Rosário Vallinoto
Mar 23, 2006·Retrovirology·Noreen SheehyWilliam Hall

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