African trypanosomes activate human fetal brain cells to proliferation and IFN-gamma production

Neuroreport
M BakhietAke Seiger

Abstract

We addressed the host-parasite interplay and the immunopathogenetic events occurring in the central nervous system (CNS) during human African trypanosomiasis. Human first trimester forebrain cells were stimulated with a trypanosome lymphocyte-triggering factor (TLTF) and studied for their immune response as exemplified by cell proliferation and IFN-gamma production. TLTF induced proliferation of human first trimester forebrain cells and IFN-gamma production at the mRNA and protein levels. Astrocytes are the major producers of IFN-gamma in response toTLTE These data illustrated for the first time a direct effect of a parasite factor on human brain cells. TargetingTLTF during the course of the disease may be considered in preventing the deadly neurological complications of human African trypanosomiasis. NeuroReport

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Citations

Sep 6, 2014·Trends in Parasitology·Stefan MogkMichael Duszenko
Oct 16, 2016·Biological Reviews of the Cambridge Philosophical Society·Stefan MogkMichael Duszenko
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·J KawanokuchiA Suzumura

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