After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group

The Journal of Infectious Diseases
E R CooperM G Fowler

Abstract

To determine the impact of the AIDS Clinical Trials Group (ACTG) Protocol 076 results on the subsequent use of zidovudine during pregnancy and the transmission rate of human immunodeficiency virus (HIV) in a cohort of mother-infant pairs (Women and Infants Transmission Study), a retrospective analysis was done. Transmission rates were calculated by simple proportion for infants with at least 6 months of follow-up, stratified by date of birth (n = 453 born on or before 1 March 1994; n = 103 born after 1 March 1994). Transmission rates decreased from 19% to 8% (P = .005, Fisher's exact test). Zidovudine use increased during pregnancy (22% vs. 89%) and in newborns (1% vs. 79%). Both cohorts were similar with respect to maternal immunosuppression, mode of delivery, and demographics. In summary, in a perinatal HIV observational study, the release of results of ACTG Protocol 076 was associated with an increase in zidovudine use during pregnancy and a concomitant decline in HIV transmission from mothers to infants.

Citations

Jul 13, 2006·Maternal and Child Health Journal·Margaret A Lampe
Oct 31, 2007·Maternal and Child Health Journal·Mayris P WebberMarc Bulterys
Aug 11, 2005·Current HIV/AIDS Reports·Michael Neely, Andrea Kovacs
Dec 3, 2003·Current Infectious Disease Reports·Michael Neely, Andrea Kovacs
Jun 8, 2002·Obstetrics and Gynecology·UNKNOWN Public Health Service Task Force Perinatal HIV Guidelines Working Group
Apr 28, 2000·Early Human Development·C Thorne, M L Newell
Jun 1, 1997·Molecular Medicine Today·A J Melvin, L M Frenkel
Nov 28, 1996·The New England Journal of Medicine·C M Wilfert
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·L Mandelbrot
Jan 11, 2000·AIDS·J E EmbreeF A Plummer
May 10, 2001·Clinical Obstetrics and Gynecology·H Minkoff
May 10, 2001·Clinical Obstetrics and Gynecology·M Khoury, A Kovacs
May 21, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L A KalishR Tuomala
Jul 17, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A LanskyP Wortley
Dec 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J PittW Shearer
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·I C HansonD E Shapiro
Jun 1, 1997·Acta Paediatrica. Supplement·M G Fowler, L Mofenson
Aug 17, 1999·Sexually Transmitted Infections·G P TaylorG Tudor-Williams
Aug 15, 2002·Paediatric Drugs·Massimo RestiFlavia Bortolotti
Apr 25, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C ChamaS Oguche
Dec 22, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C ChamaW Gashau
Aug 29, 2003·Expert Opinion on Investigational Drugs·Athena P Kourtis, Ann Duerr
Sep 5, 2012·Enfermedades infecciosas y microbiología clínica·Marina Holgado-JuanJosé Tomás Ramos-Amador
Mar 4, 2000·Pediatric Clinics of North America·M G FowlerA Roongpisuthipong
Mar 4, 2000·Pediatric Clinics of North America·E J Abrams

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