Abstract
The aim of the study was to investigate blood alterations caused by altitude acclimatization which last more than few days after return and might play a role for exercise performance at sea level. Measurements were performed in 12 mountaineers before, during and either 7/8 or 11/12 days after a Himalaya expedition (26-29 days at 4900 to 7600 m altitude). [Erythropoietin] rose only temporarily at altitude (max. +11 +/- 1 [SE] mu/ml serum). After return hemoglobin mass (initially 881 +/- 44 g, CO-Hb method) was increased by 14% (p < 0.01); aspartate aminotransferase activity in erythrocytes (initially 682 +/- 25 U/l) was augmented (day 7: +964 +/- 152 U/l, day 11: +533 +/- 107 U/l) indicating reduced mean cell age. Calculated blood volume (+14%) was influenced by red cell formation at altitude but also by plasma expansion at sea level. The half saturation pressure for Hb-O2 (pH 7.4, 37 degrees C) as well as the 2.3-diphosphoglycerate concentration were already initially high (32.1 +/- 0.5 mmHg, 20.5 +/- 0.7 mumol/g Hb) and showed only a nonsignificant tendency to increase after return. Also Hill's n was consistently high in the mountaineers, whereas the Bohr coefficients were slightly increased only after descent. Probably the pr...Continue Reading
Citations
May 8, 2013·PloS One·Binfeng HeGuansong Wang
Jun 19, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Yohan RobinsonDieter Böning
Jun 3, 2015·Pakistan Journal of Biological Sciences : PJBS·Yones HematyMonir Doudi
Jul 10, 2001·High Altitude Medicine & Biology·T D Brutsaert
Jun 13, 2009·High Altitude Medicine & Biology·Philo U SaundersChristopher J Gore
Oct 14, 2004·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Yohan RobinsonDieter Böning
Oct 9, 2009·Sleep & Breathing = Schlaf & Atmung·Markus TannheimerRoland Schmidt
Nov 10, 2012·European Journal of Applied Physiology·N B WachsmuthW Schmidt
Sep 9, 2008·Scandinavian Journal of Medicine & Science in Sports·W Schmidt, N Prommer
Jan 8, 2005·The Veterinary Clinics of North America. Equine Practice·Kenneth Harrington McKeever
Feb 26, 2016·Experimental Physiology·Benjamin J RyanWilliam C Byrnes
Oct 2, 2014·PloS One·Benjamin J RyanRobert C Roach
Sep 7, 2016·Physiological Reports·Edgar CristanchoDieter Böning
Sep 16, 2017·European Journal of Applied Physiology·Olaf LühkerMarcel Hochreiter
Dec 3, 2009·Medicine and Science in Sports and Exercise·Nicole PrommerWalter Schmidt
Dec 17, 2005·Journal of Applied Physiology·Stefan Keslacy
Jan 13, 2006·Journal of Applied Physiology·Bernd Wolfarth